泛昔洛韦预防多发性骨髓瘤并发带状疱疹的有效性及对细胞因子IL-2、IL-10的影响

Efficacy of Famciclovir in the Prevention of Multiple Myeloma Complicated with Herpes Zoster and Its Effect on Cytokines IL-2 and IL-10

目的:探讨泛昔洛韦在多发性骨髓瘤中预防带状疱疹的有效性及对细胞因子白细胞介素-2(IL-2)、白细胞介素-10(IL-10)的影响。方法:回顾性选取2020年2月-2021年2月赣南医学院第一附属医院收治的多发性骨髓瘤患者60例,依据治疗方法分为观察组和对照组,各30例。对照组接受硼替佐米联合环磷酰胺、地塞米松(BCD)方案化疗,观察组在对照组基础上口服泛昔洛韦,统计分析两组化疗过程中的不良反应发生情况及带状疱疹发生率、实验室指标、疼痛程度、临床疗效、满意度。结果:观察组不良反应发生率为10.00%(3/30),低于对照组的33.33%(10/30)(P<0.05);带状疱疹发生率为3.33%(1/30),低于对照组的20.00%(6/30)(P<0.05)。治疗后,观察组IL-10水平低于对照组(P<0.05),IL-2水平高于对照组(P<0.05)。治疗后,观察组VAS评分低于对照组(P<0.05)。两组临床疗效比较,差异无统计学意义(P>0.05)。观察组满意度为93.33%(28/30),高于对照组的66.67%(20/30)(P<0.05)。结论:泛昔洛韦能够有效降低多发性骨髓瘤治疗过程带状疱疹的发生率,并有效提升细胞因子IL-2水平,降低IL-10水平。

Objective:To investigate the efficacy of Famciclovir in the prevention of herpes zoster in multiple information myeloma and its effect on cytokines interleukin-2(IL-2)and interleukin-10(IL-10).Method:A total of 60 patients with multiple myeloma admitted to First Affiliated Hospital of Gannan Medical University from February 2020 to February 2021 were retrospectively selected and divided into observation group and control group according to the treatment methods,with 30 cases in each group.The control group received Bortezomib combined with Cyclophosphamide and Dexamethasone(BCD)regimen chemotherapy,while the observation group received Famciclovir orally on the basis of the control group.The adverse reactions,incidence of herpes zoster during chemotherapy,laboratory indicators,pain degree,clinical efficacy and satisfaction of the two groups were statistically analyzed.Result:The rate of adverse reactions during chemotherapy in the observation group was 10.00%(3/30),which was lower than 33.33%(10/30)in the control group(P<0.05);the incidence of herpes zoster was 3.33%(1/30),which was lower than 20.00%(6/30)in the control group(P<0.05).After treatment,the level of IL-10 in the observation group was lower than that in the control group(P<0.05),and the level of IL-2 in the observation group was higher than that in the control group(P<0.05).After treatment,the VAS score of the observation group was lower than that in the control group(P<0.05).There was no significant difference in clinical efficacy between the two groups(P>0.05).The satisfaction of patients in the observation group was 93.33%,which was higher than 66.67%in the control group(P<0.05).Conclusion:Famciclovir can effectively reduce the incidence of herpes zoster during the treatment of multiple myeloma,and effectively increase the level of cytokine IL-2 and reduce the level of IL-10.