帕洛诺司琼治疗剖宫产围术期使用卡前列素氨丁三醇所致恶心呕吐的效果

Effect of Palonosetron in the Treatment of Nausea and Vomiting Caused by Carprost Troamine during Perioperative Period of Cesarean Section

目的探讨帕洛诺司琼治疗剖宫产围术期使用卡前列素氨丁三醇所致恶心呕吐的临床效果。方法选取2022年1—9月淄博市妇幼保健院收治的剖宫产围术期出现恶心呕吐者80例,按照随机数表法分为对照组及观察组,各40例。所有入组者均接受腰硬联合麻醉下剖宫产手术,观察组静脉滴注帕洛诺司琼,对照组静脉滴注甲氧氯普胺。比较两组患者恶心、呕吐评分缓解时间,治疗前后恶心呕吐评分,给药后30 min患者生命体征变化情况及其他不适情况。结果观察组恶心缓解时间和呕吐缓解时间分别为(2.3±0.2)h和(4.1±0.5)h均显著早于对照组,差异有统计学意义(t=11.437、7.569,P<0.05)。治疗后观察组恶心呕吐评分为(0.5±0.1)分,低于对照组,差异有统计学意义(t=20.000,P<0.05)。观察组给药后30 min心率和呼吸频率分别为(85.2±12.1)、(15.2±3.3)次/min均慢于对照组,差异有统计学意义(t=6.687、12.098,P<0.05),平均动脉压和血氧饱和度分别为(85.5±5.5)mmHg和(98.8±1.1)%,均高于对照组,差异有统计学意义(t=13.276、15.283,P<0.05)。观察组发生胸闷、呼吸困难、面色潮红和低血压的总比例为1例(2.5%)低于对照组的10例(25.0%),差异有统计学意义(χ^(2)=8.538,P<0.05)。结论帕洛诺司琼可快速的缓解使用卡前列素氨丁三醇后导致的恶心呕吐不适,更好地维持患者术中生命体征平稳,同时对降低使用卡前列素氨丁三醇后的其他不适症状亦有一定帮助。

Objective To investigate the clinical effect of palonosetron in the treatment of nausea and vomiting caused by carprost troamine during perioperative period of cesarean section.Methods 80 patients with nausea and vomiting during cesarean section admitted to Zibo Maternal and Child Health Hospital from January to September 2022 were selected,and divide them into control group and observation group according to random number table method,with 40 patients in each group.All patients in the group received cesarean section under combined spinal-epidural anesthesia.Palonosetron was given intravenously in the observation group,and metoclopramide was given intravenously in the control group.The remission time of nausea and vomiting scores,nausea and vomiting scores before and after treatment,changes in vital signs of patients 30 minutes after administration and other discomfort were compared between the two groups of patients.Results The remission time of nausea and vomiting in the observation group were(2.3±0.2)h and(4.1±0.5)h respectively,which were significantly earlier than those in the control group,the difference was statistically significant(t=11.437,7.569,P<0.05).After treatment,the score of nausea and vomiting in the observation group was(0.5±0.1)points,lower than that in the control group,the difference was statistically significant(t=20.000,P<0.05).The heart rate and respiratory rate of the observation group were(85.2±12.1)beats/min and(15.2±3.3)beats/min respectively 30 minutes after administration,and the difference was statistically significant(t=6.687,12.098,P<0.05).The mean arterial pressure and blood oxygen saturation were(85.5±5.5)mmHg and(98.8±1.1)%respectively,were higher than those of the control group,and the difference was statistically significant(t=13.276,15.283,P<0.05).The total proportion of chest tightness,dyspnea,flushing and hypotension in the observation group was 1 case(2.5%),lower than that in the control group 10 cases(25.0%),the difference was statistically significant(χ^(2)=8.538,P<0.05).Conclusion Palonosetron can quickly relieve the nausea and vomiting caused by the use of carprost troamine,better maintain the patient's intraoperative vital signs stable,and reduce other symptoms of discomfort after the use of carprost troamine,which is also helpful.