分析硫酸镁与硝苯地平联合治疗妊娠期高血压综合征对其脐血流指数的影响

Effect of Magnesium Sulfate Combined with Nifedipine on Cord Blood Flow Index of Hypertensive Syndrome during Pregnancy

目的探讨对妊娠期高血压综合征患者采用硫酸镁+硝苯地平药物联合治疗后对其脐血流指数等产生的影响。方法选取2019年1月—2021年12月常熟市第二人民医院收治的101例妊娠期高血压综合征患者进行研究。随机分为常规组(50例,采用硫酸镁药物治疗)和研究组(51例,采用硫酸镁+硝苯地平药物治疗)。比较两组患者治疗总有效率、血压指标[舒张压(DBP)、收缩压(SBP)]、血压达标时间、24 h尿蛋白定量、红细胞压积(HCT)、血浆黏度(PV)以及脐血流指数(S/D)。结果研究组治疗总有效率(96.08%)较常规组(78.00%)高,差异有统计学意义(χ^(2)=7.358,P<0.05)。治疗前,研究组DBP(102.19±6.35)mmHg、SBP(172.31±15.59)mmHg与常规组对比,差异无统计学意义(P>0.05);治疗后,研究组DBP(83.52±4.33)mmHg、SBP(130.22±11.83)mmHg较常规组降低,差异有统计学意义(P<0.05)。研究组血压达标时间(7.59±1.99)d较常规组缩短,差异有统计学意义(P<0.05);研究组24 h尿蛋白定量(1.35±0.29)g较常规组降低,差异有统计学意义(P<0.05)。治疗前,研究组HCT(45.29±2.53)%、PV(1.99±2.53)mp·s以及S/D(2.69±0.59)与常规组对比,差异无统计学意义(P>0.05);治疗后,研究组HCT(25.33±3.96)%、PV(1.26±0.53)mp·s以及S/D(2.31±0.25)较常规组降低,差异有统计学意义(P<0.05)。结论硫酸镁+硝苯地平药物联合应用,可显著提高患者治疗效果,降低血压水平,缩短血压达标时间,此外可显著改善24 h尿蛋白定量、HCT、PV以及S/D,促进妊娠期高血压综合征患者获得良好预后。

Objective To investigate the effect of magnesium sulfate combined with nifedipine on umbilical cord blood flow index in hypertensive syndrome during pregnancy.Methods 101 patients with hypertensive syndrome during pregnancy admitted to Changshu Second People's Hospital from January 2019 to December 2021 were selected for study.They were randomly divided into routine group(50 cases,treated with magnesium sulfate)and study group(51 cases,treated with magnesium sulfate+nifedipine).The total effective rate of treatment,blood pressure indicators[diastolic blood pressure(DBP),systolic blood pressure(SBP)],time of reaching the standard of blood pressure,24-hour urine protein content,hematocrit(HCT),plasma viscosity(PV)and umbilical blood flow index(S/D)were compared between the two groups.Results The total effective rate of treatment in the study group(96.08%)was higher than that in the routine group(78.00%),and the difference was statistically significant(χ^(2)=7.358,P<0.05).Before treatment,there was no statistically significant difference in DBP(102.19±6.35)mmHg and SBP(172.31±15.59)mmHg between the study group and the routine group(P>0.05);after treatment,DBP(83.52±4.33)mmHg and SBP(130.22±11.83)mmHg in the study group were lower than those in the routine group,and the difference was statistically significant(P<0.05).The time of reaching the standard of blood pressure in the study group was(7.59±1.99)days shorter than that in the routine group,and the difference was statistically significant(P<0.05).The 24-hour urine protein quantitative(1.35±0.29)g in the study group was lower than that in the routine group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in HCT(45.29±2.53)%,PV(1.99±2.53)mp·s and S/D(2.69±0.59)between the study group and the routine group(P>0.05);after treatment,HCT(25.33±3.96)%,PV(1.26±0.53)mp·s and S/D(2.31±0.25)in the study group were significantly lower than those in the routine group,and the difference was statistically significant(P<0.05).Conclusion The combined use of magnesium sulfate and nifedipine can significantly improve the treatment effect of patients,reduce the blood pressure level,shorten the time of reaching the standard of blood pressure,in addition,it can significantly improve the 24-hour urine protein content,HCT,PV and S/D,and promote the good prognosis of patients with pregnancy induced hypertension syndrome.