黄芪桂枝五物汤加味联合倍他司汀注射液治疗椎动脉型颈椎病的临床效果

Clinical effect of modified Huangqi Guizhi Wuwu decoction combined with betahistine injection in the treatment of cervical spondylosis of vertebral artery type

目的 研究黄芪桂枝五物汤加味联合倍他司汀注射液治疗椎动脉型颈椎病的临床效果。方法 选取2018年1月至2020年12月本院收治的116例椎动脉型颈椎病患者为研究对象,按照治疗方法的不同将其分为对照组和观察组,每组58例。对照组予以倍他司汀注射液治疗,观察组实施黄芪桂枝五物汤加味联合倍他司汀注射液治疗。比较两组的椎-基底动脉血流动力学指标、临床症状体征评分、改良颈性眩晕症状与功能评估量表(ESCV)评分及治疗安全性。结果 治疗2周后,两组的椎-基底动脉血流动力学指标均优于治疗前,且观察组优于对照组(P<0.05)。治疗2周后,两组的各项临床症状体征评分及总分低于治疗前,且观察组低于对照组(P<0.05)。治疗2周后,两组的ESCV各维度评分及总分均升高,且观察组高于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论 黄芪桂枝五物汤加味联合倍他司汀注射液治疗椎动脉型颈椎病安全有效,可促进椎-基底动脉血流循环以及临床症状体征的改善。

Objective To study the clinical effect of modified Huangqi Guizhi Wuwu decoction combined with betahistine injection in the treatment of cervical spondylosis of vertebral artery type.Methods A total of 116 patients with cervical spondylosis of vertebral artery type admitted in our hospital from January 2018 to December 2020 were selected as the research objects.According to different treatment methods,the patients were divided into control group and observation group,with 58 cases in each group.The control group was treated with betastine injection,and the observation group was treated with modified Huangqi Guizhi Wuwu decoction combined with betastine injection.The vertebral-basilar artery hemodynamics indexes,clinical signs and symptoms scores,Evaluation Scale for Cervical Vertigo(ESCV)score and treatment safety were compared between the two groups.Results After 2 weeks of treatment,the vertebral-basilar artery hemodynamics indexes of both groups were better than those before treatment,and those in the observation group were better than the control group(P<0.05).After 2 weeks of treatment,the clinical symptoms and signs scores and total score in both groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).After 2 weeks of treatment,the scores of all dimensions of ESCV and total score increased in both groups,and those in the observation group were higher than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Huangqi Guizhi Wuwu decoction combined with betastine injection is safe and effective in the treatment of cervical spondylosis of vertebral artery type,which can promote the improvement of vertebral-basilar artery blood circulation and clinical symptoms and signs.