正畸联合牙周治疗对牙周炎致前牙移位患者口腔状态指标及炎症反应的影响

Effect of Orthodontic Combined with Periodontal Treatment on Oral Status Indexes and Inflammatory Response in Patients with Anterior Tooth Displacement Caused by Periodontitis

目的:探讨正畸联合牙周治疗对牙周炎致前牙移位患者口腔状态指标及炎症反应的影响。方法:选择2017年1月-2019年1月于宁波口腔医院治疗的160例牙周炎致前牙移位患者,使用随机数字表法将其分为观察组(n=80)和对照组(n=80)。对照组接受牙周治疗,观察组接受正畸联合牙周治疗。对比两组总有效率、口腔状态指标、炎症反应指标及骨代谢指标。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组牙周探诊深度(PD)、探诊出血指数(PBI)、牙齿松动度(TM)、菌斑指数(PLI)比较,差异均无统计学意义(P>0.05);治疗后,两组PD、PBI、TM、PLI均降低,且观察组均低于对照组(P<0.05)。治疗前,两组血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-5(IL-5)、白介素-8(IL-8)水平比较,差异均无统计学意义(P>0.05);治疗后,两组TNF-α、IL-1β、IL-5、IL-8均降低,且观察组均低于对照组(P<0.05)。治疗前,两组骨钙素(OCN)、骨保护素(OPG)、破骨细胞分化因子(RANKL)比较,差异均无统计学意义(P>0.05);治疗后,两组OCN、OPG均升高,观察组均高于对照组(P<0.05),两组RANKL均降低,观察组低于对照组(P<0.05)。结论:正畸联合牙周治疗可显著改善牙周炎致前牙移位患者口腔状态、降低炎症因子水平,总体治疗效果理想,值得推广。

Objective:To investigate the effect of orthodontic combined with periodontal treatment on the oral status indexes and inflammatory response in patients with anterior tooth displacement caused by periodontitis.Method:A total of 160 patients with anterior tooth displacement caused by periodontitis treated in Ningbo Stomatology Hospital from January 2017 to January 2019 were selected and divided into observation group(n=80)and control group(n=80)by the random number table method.The control group received periodontal treatment and the observation group received orthodontic treatment in combination with periodontal treatment.The total effective rate,oral status indexes,inflammatory response indexes and bone metabolism indexes of the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,the periodontal probing depth(PD),probing bleeding index(PBI),tooth mobility(TM),plaque index(PLI)were not significantly different between the two groups(P>0.05);after treatment,PD,PBI,TM,PLI were decreased in both groups,and the observation group were lower than those of the control group(P<0.05).Before treatment,the levels of serum hypersensitive C reactive protein(hs-CRP),tumour necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-5(IL-5)and interleukin-8(IL-8)were not significantly different between the two groups(P>0.05);after treatment,TNF-α,IL-1β,IL-5 and IL-8 were decreased in both groups,the observation group were lower than those of the control group(P<0.05).Before treatment,the differences in osteocalcin(OCN),osteoprotegerin(OPG)and receptor activator of NF-κB ligand(RANKL)between the two groups were not significant(P>0.05);after treatment,the OCN and OPG increased in both groups,the observation group were higher than those of control group(P<0.05),the RANKL decreased in both groups,the observation group was lower than that of the control group(P<0.05).Conclusion:Orthodontic combined with periodontal treatment can significantly improve the oral status of patients with anterior tooth displacement caused Medical Innovation of China Vol.20,No.14 May,2023 by periodontitis,reduce the level of inflammatory factors,and the overall treatment effect is ideal and worthy of promotion.