三阴性乳腺癌患者短期预后的影响因素分析

Analysis of Influencing Factors of Short-term Prognosis in Patients with Triple-negative Breast Cancer

目的:探究与分析影响三阴性乳腺癌患者短期预后的高危因素。方法:回顾性分析江西省肿瘤医院2016年4月-2019年4月收治的99例三阴性乳腺癌患者的临床资料,并对患者一般情况、临床病理特征及治疗方法的相关资料进行分析,观察患者3年内生存情况,将生存患者纳入生存组(n=77),死亡患者纳入死亡组(n=22),采用单因素及多因素logistic回归分析探讨影响三阴性乳腺癌患者短期预后的影响因素。结果:三阴性乳腺癌患者共99例,均进行了为期3年的随访,发现死亡22例(死亡组),死亡率为22.22%(22/99),生存77例(生存组),生存率为77.78%(77/99)。死亡组患者中居住农村、未生育、无哺乳史、淋巴结阳性、未接受新辅助化疗占比均较生存组高,NLR及Ki67指数均较生存组高,差异均有统计学意义(P<0.05);两组体重指数(BMI)、家族史、肿瘤生长位置、月经状态、初潮年龄、初产年龄、原发肿瘤分期、AJCC分期、病理组织学分级、手术方式比较,差异均无统计学意义(P>0.05)。多因素logistic回归分析显示,未生育、淋巴结阳性是影响三阴性乳腺癌患者短期预后的独立危险因素,有哺乳史、接受新辅助化疗为三阴性乳腺癌患者的保护性因素(P<0.05)。结论:在临床工作中需对影响三阴性乳腺癌患者预后的危险因素引起足够的重视,由此辅助三阴性乳腺癌患者获得更好的预后。

Objective:To explore and analyze the high risk factors affecting the short-term prognosis of patients with triple-negative breast cancer.Method:The clinical data of 99 patients with triple-negative breast cancer admitted to Jiangxi Cancer Hospital from April 2016 to April 2019 were retrospectively analyzed,and the relevant data of patients'general situation,clinicopathological characteristics and treatment methods were analyzed.The survival situation of patients within 3 years was observed,the surviving patients were included in the survival group(n=77)and the dead patients were included in patients with cluded in the death group(n=22).Univariate and multivariate logistic regression analysis was used to explore the influencing factors of short-term prognosis of in patients with triple-negative breast cancer.Result:A total of 99 patients with triple negative breast cancer were followed up for three years.Among them,22 cases died(death group),the mortality rate was 22.22%(22/99),77 cases survived(survival group),and the survival rate was 77.78%(77/99).The proportion of patients in the death group who lived in rural areas,had no childbearing,no breastfeeding history,positive lymph nodes,and not receive neoadjuvant chemotherapy were higher than those in the survival group,the NLR and Ki67 index were higher than those in the survival group,the differences were statistically significant(P<0.05).There were no statistically significant differences in body mass index(BMI),family history,tumor growth location,menstrual state,menarche age,initial delivery age,primary tumor staging,AJCC staging,histopathological grading,and surgical method between the two groups(P>0.05).Multivariate logistic regression analysis showed that had no childbearing and positive lymph nodes are independent risk factors affecting the short-term prognosis of patients with triple-negative breast cancer,while had breastfeeding history and receive neoadjuvant chemotherapy are protective factors of patients with triple-negative breast cancer(P<0.05).Conclusion:In clinical work,enough attention should be paid to the risk factors affecting the prognosis of patients with triple-negative breast cancer,so as to assist the triple-negative breast cancer patients to obtain a better prognosis.