2型糖尿病患者下肢血管病变程度与血清指标的相关性

Correlation between severity of lower extremity peripheral artery disease and serum indicators in patients with type 2 diabetes mellitus

探究2型糖尿病患者下肢血管病变(PAD)程度与血清生化指标的关系。102例糖尿病患者依据踝肱指数(ABI)分为非下肢血管病变(N-PAD)、轻度(A-PAD)、中度(B-PAD)和重度(C-PAD)下肢血管病变组,30例健康人群为对照组,分析PAD程度与血清生化指标关系。与对照组相比,N-PAD组、A-PAD组、B-PAD组和C-PAD组的空腹血糖(FPG)、TC、TG、LDL-C升高,而HDL-C、25羟维生素D[25-(OH)D]降低(P<0.05);PAD程度与FPG正相关,与25-(OH)D负相关(P<0.05)。糖尿病患者FPG、25-(OH)D与下肢血管病变发生密切相关。

The purpose of this study was to investigate the relationship between the severity of lower extremity peripheral artery disease(PAD)and serum biochemical indicators in the patients with type 2 diabetes mellitus.A total of 102 diabetic patients were divided into non-lower extremity PAD(N-PAD),mild-lower extremity PAD(A-PAD),moderate-lower extremity PAD(B-PAD)and severe-lower extremity PAD(C-PAD)groups based on ankle-brachial index(ABI),and 30 healthy subjects were included as the control group.The relationship between the severity of PAD and serum biochemical indicators was analyzed,respectively.Compared with the control group,the serum levels of fasting plasma glucose(FPG),total cholesterol(TC),triglycerides(TG),and low-density lipoprotein-C(LDL-C)increased,while the serum levels of high-density lipoprotein cholesterol(HDL-C)and 25 hydroxyvitamin D[25-(OH)D]decreased,in the N-PAD,A-PAD,B-PAD,and C-PAD groups(all P<0.05).The severity of PAD was positively correlated with the serum level of FPG,and negatively correlated with the serum level of 25-(OH)D(both P<0.05).In conclusion,the serum levels of FPG and 25-(OH)D may be closely associated with the development of lower extremity PAD in diabetic patients.