反应蛋白水平、降钙素原对于评估糖尿病足感染严重程度判定及预后评估的价值研究

The Value of C-reactive Protein Levels and Procalcitonin in Assessing the Severity of Diabetic Foot Infection and Prognostic Assessment

目的探讨反应蛋白(CRP)水平、降钙素原(PCT)对于评估糖尿病足感染严重程度判定及预后评估的价值研究。方法选取龙岩市第二医院2019年1月—2020年10月收治的100例糖尿病足感染患者作为研究对象,详细记录患者的临床资料,按照糖尿病足感染程度分为重度组、中度组、轻度组,按照预后不同分为截趾组和非截趾组,比较不同感染程度组别患者一般资料及CRP、PCT水平,危险因素分析以及ROC曲线分析。结果3组患者年龄、糖尿病病程、糖尿病足感染病程对比>差异无统计学意义(P>0.05);随着病情程度的加重,CRP、PCT水平逐渐升高,差异有统计学意义(P<0.05)。截趾组CRP、PCT水平及骨髓炎、肢体缺血例数高于非截趾组,差异有统计学意义(P<0.05)。经Logistic回归分析,骨髓炎、肢体缺血是患者截趾的危险因素,CRP、PCT预测患者AUC分别为0.855、0.897(P<0.05)。结论检测血清CRP、PCT水平有助于判断糖尿病足感染患者严重程度,对于截趾的预测价值,基线PCT优于基线CRP。

Objective To investigate the value of C-reactive protein(CRP)level and procalcitonin(PCT)in assessing the severity of diabetic foot infection(DFI)and prognostic assessment.Methods One hundred patients with diabetic foot infection admitted to Longyan Second Hospital from January 2019 to October 2020 were selected as study subjects,and the clinical data of the patients were recorded in detail.According to the degree of diabetic foot infection,they were divided into severe group,moderate group and mild group.According to the different prognosis,they were divided into amputation group and non-amputation group,and the general data and CRP and PCT levels,risk factor analysis and ROC curve analysis were compared among patients in different infection degree groups.Results There was no statistically significant difference in age,course of diabetes and course of diabetes foot infection among,the three groups(P>0.05);as the severity of the disease worsens,the levels of CRP and PCT gradually increase,the difference was statistically significant(P<0.05).The CRP and PCT levels and the number of cases of osteomyelitis and limb ischemia in the toe amputation group were higher than those in the non-amputation group,the difference was statistically significant(P<0.05).By Logistic regression analysis,osteomyelitis,limb ischemia,and were risk factors for toe amputation in patients,and CRP and PCT predicted patient AUC of 0.855 and 0.897,respectively(P<0.05).Conclusion The detection of serum CRP and PCT levels can help determine the severity of patients with diabetic foot infection,and for the predictive value of amputation,baseline PCT was superior to baseline CRP.