达格列净联合阿卡波糖治疗初诊2型糖尿病的药学分析

Pharmaceutical Analysis of Dapagliflozin Combined with Acarbose in the Treatment of Newly Diagnosed Type 2 Diabetes Mellitus

目的评估达格列净+阿卡波糖应用在初诊2型糖尿病(type 2 diabetes mellitus,T2DM)患者中的效果及药学作用分析。方法纳入2020年9月—2021年12月汉川市第二人民医院收治的71例初诊T2DM患者作为研究对象。全部受试者以随机数表法分为对照组(纳入36例,行阿卡波糖治疗)、观察组(纳入35例,行达格列净+阿卡波糖治疗),评价两组血糖相关参数、血压、体质量、胰岛功能、血脂代谢指标、用药不良反应。结果治疗1个月后,观察组血糖相关参数(餐后2 h血糖、空腹血糖、糖化血红蛋白)、舒张压、收缩压、体质量、胰岛功能(胰岛β细胞功能指数、胰岛素抵抗指数、空腹C肽)、血脂代谢指标(低密度脂蛋白胆固醇、三酰甘油、总胆固醇)较对照组更佳,差异有统计学意义(P<0.05)。在用药不良反应方面,观察组(8.57%)与对照组(5.56%)比较,差异无统计学意义(P>0.05)。结论对初诊T2DM患者行达格列净+阿卡波糖治疗,能够改善胰岛β细胞功能、血脂指标,降低血压及体质量,增强血糖控制效果,加之不良反应少。

Objective To evaluate the effect of Dapagliflozin plus acarbose on newly diagnosed patients with type 2 diabetes mellitus(T2DM).Methods 71 newly diagnosed T2DM patients admitted to the Second People's Hospital of Hanchuan City from September 2020 to December 2021 were included as the study subjects.All subjects were randomly divided into control group(thirty-six patients included,receiving acarbose treatment)and observation group(thirty-five patients included,receiving Dapagliflozin+acarbose treatment).Glycemic parameters,blood pressure,body weight,islet function,lipid metabolism indexes and adverse drug reaction were evaluated between the two groups.Results After one month of treatment,the blood glucose related parameters(2-hour postprandial blood glucose,fasting blood glucose,glycosylated hemoglobin),diastolic blood pressure,systolic blood pressure,body mass,and islet function(islet functionβcell function index,insulin resistance index,fasting C-peptide),and lipid metabolism index(low density lipoprotein cholesterol,triacylglycerol,and total cholesterol)in the observation group were better than those in the control group,the difference was statistically significant(P<0.05).In terms of adverse drug reactions,there was no statistically significant difference between the observation group(8.57%)and the control group(5.56%)(P>0.05).Conclusion Dapagliflozin+acarbose therapy in newly diagnosed T2DM patients can improve pancreaticβcell function,lipid indexes,reduce blood pressure and body weight,enhance blood glucose control effect,and have fewer adverse reactions.