摘要
INTRODUCTION The emergence of coronavirus disease 2019(COVID-19)has posed a significant threat to global health and well-being.Vaccination serves as a vital strategy in preventing and mitigating the severity of clinical symptoms.However,due to natural selection,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has evolved,resulting in various mutations(1).Currently,the World Health Organization(WHO)has identified five variants of concern,including Alpha,Beta,Gamma,Delta,and Omicron(2).Of these,only Omicron remains in circulation and has already produced nearly one thousand sub-lineages or subvariants.These mutating variants demonstrate increased infectivity and vaccine breakthrough rates,as well as more pronounced antibody escape rates(3).
基金
National Key Research and Development Program of China(Grant numbers 2022YFF1103100 and 2019YFC1605900)
2022 Strategic Research and Consulting Project of Chinese Academy of Engineering.
