摘要
极光激酶B(Aurora kinase B,AURKB)属于极光激酶家族,是一种参与有丝分裂的丝氨酸/苏氨酸蛋白激酶,在细胞周期中起着重要的调节作用。近年来研究发现,AURKB在一些癌症中高表达,与癌症发生发展密切相关,有望成为新的治疗靶点。本文就AURKB的结构、功能和定位,以及AURKB调控肿瘤发生发展所依赖的具体分子机制等方面进行综述,以期为癌症靶向治疗提供重要思路。
Aurora Kinase B(AURKB)belongs to the Aurora Kinase family,a serine/threonine protein kinase involved in mitosis,and plays an important regulatory role in the cell cycle.In recent years,AURKB has been found to be highly expressed in some cancer samples,andithas also been shown to play critical roles in oncogenesis,making it apotential therapeutic target.This paper reviews the structure,function and localization of AURKB,and the specific molecular mechanisms underlying the regulation of cancerdevelopment by AURKB,with the aim of providing guidance for cancer targeted therapy.
作者
张峰华
张顺美
朱奕帆
甘滔
ZHANG Feng-hua;ZHANG Shun-mei;ZHU Yi-fan;GAN Tao(School of Rehabilitation,Gannan Medical University;School of Basic Medicine,Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医学院学报》
2023年第4期343-349,共7页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
国家自然科学基金资助项目(31960201)
赣南医学院校级科技创新团队课题(TD201903)
赣南医学院校级重点课题(ZD201702)。
关键词
极光激酶B
极光激酶
癌症
靶向治疗
Aurora kinase B
Aurora kinase
Cancer
Targeted therapy
