银屑病与代谢合并症的遗传关系研究进展

Advances in the study of genetic links between psoriasis and metabolic comorbidity

银屑病是一种常见的炎症性皮肤病,由多种遗传和环境危险因素相互作用引起。与一般人群相比,银屑病患者高血压、胰岛素抵抗和2型糖尿病、血脂异常、肥胖的患病率更高。银屑病代谢合并症影响疾病严重程度,降低患者生活质量,甚至缩短患者预期寿命。研究表明,银屑病和许多代谢性疾病存在共同的遗传因素。本文综述并探讨高血压、肥胖、血脂异常、糖尿病与银屑病在遗传方面的关系,分析银屑病与这4种慢性代谢性疾病的共同遗传基础,为银屑病和代谢合并症的防治和银屑病管理的改善提供依据。

Psoriasis is a common inflammatory skin disease caused by the interaction of multiple genetic and environmental risk factors.Patients with psoriasis have a higher prevalence of hypertension,insulin resistance and type 2 diabetes,dyslipidaemia and obesity compared to the general population.The metabolic comorbidity of psoriasis affects the severity of the disease,reduces the quality of life of patients and even leads to a shorter life expectancy.Studies have shown that psoriasis and many metabolic disorders share a common genetic component.This paper reviews and examines the genetic links between hypertension,obesity,dyslipidaemia,diabetes and psoriasis,and analyses the common genetic basis of psoriasis and these four chronic metabolic diseases,in order to provide a basis for the prevention and treatment of psoriasis and metabolic comorbidity and to improve the management of psoriasis.