急性髓系白血病患者外周血FOXO1、PBX3的表达及对预后的预测价值

Expression of FOXO1 and PBX3 in Peripheral Blood of Patients with Acute Myeloid Leukemia and Their Predictive Value for Prognosis

目的:探讨急性髓系白血病(AML)患者外周血叉头框转录因子O1(FOXO1)、B细胞白血病同源盒基因3(PBX3)的表达及对预后的预测价值。方法:前瞻性选取2017年8月至2021年8月收治的60例急性髓系白血病患者作为研究对象。所有患者均随访1年并按照随访结果分为预后良好组(36例)和预后不良组(24例)。采用Pearson检验进行相关性分析;采用logistics回归模型分析AML患者预后的独立危险因素;采用ROC曲线分析FOXO1、PBX3对AML患者预后的预测价值。结果:预后良好组和预后不良组年龄、性别、BMI比较无显著差异(P>0.05),而在血小板、中性粒细胞比值、FOXO1、PBX3、白细胞计数存在显著差异(P<0.05);FOXO1、PBX3与血小板、中性粒细胞比值、白细胞计显著正相关(P<0.05);多因素分析结果显示,血小板、中性粒细胞比值、FOXO1、PBX3、白细胞计数是影响急性髓系白血病患者预后的独立危险因素(P<0.05);血清FOXO1、PBX3预测AML患者预后的灵敏度和特异性达到91.31%和92.31%。结论:急性髓系白血病患者外周血FOXO1、PBX3的表达上调可作为预测评估其预后发展的可靠血清标志物。

Objective:To investigate the expressions of FOXO1 and PBX3 in peripheral blood of patients with acute myeloid leukemia(AML)and their predictive value for prognosis.Methods:Sixty patients with acute myeloid leukemia admitted from August 2017 to August 2021 were prospectively selected as the study subjects.All patients were followed up for 1 year and were divided into a good prognosis group(36 cases)and a poor prognosis group(24 cases)according to the follow-up results.Pearson test was used for correlation analysis;logistic regression model was used to analyze the independent risk factors for the prognosis of AML patients;ROC curve was used to analyze the predictive value of FOXO1 and PBX3 on the prognosis of AML patients.Results:There was no significant difference in age,gender and BMI between the good prognosis group and the poor prognosis group(P>0.05),but there were significant differences in platelet,neutrophil ratio,FOXO1,PBX3,and white blood cell count(P<0.05);FOXO1,PBX3 were positively correlated with platelet,neutrophil ratio,and white blood cell count(P<0.05);multivariate analysis showed that platelet,neutrophil ratio,FOXO1,PBX3,and white blood cell count were the prognoses of patients with acute myeloid leukemia.The independent risk factors of AML(P<0.05);the sensitivity and specificity of serum FOXO1 and PBX3 in predicting the prognosis of AML patients reached 91.31%and 92.31%.Conclusion:The up-regulated expressions of FOXO1 and PBX3 in peripheral blood of patients with acute myeloid leukemia can be used as reliable serum markers to predict and evaluate their prognosis.