党参的研究进展及其质量标志物的预测分析

Research progress of Codonopsis Radix and prediction of its Q-markers

党参是我国传统的补益类大宗药材,具有健脾益肺、养血生津等功效。党参属植物中化学成分主要有聚炔类、生物碱类、苯丙素类、木脂素类、三萜及皂苷类、黄酮类、甾体类、有机酸类、糖类等,现代药理学研究表明,党参还具有增强机体免疫力、保护胃肠道黏膜及抗溃疡、促进造血机能、调节血糖、延缓衰老等多种药理作用。该文对党参属植物的化学成分、党参药理作用等进行梳理总结,并在此基础上对党参的质量标志物进行分析,预测党参炔苷、党参苷Ⅰ、管花党参碱A、党参低聚糖等为其可能的质量标志物,为党参质量评价体系的建立和深入研究开发提供科学参考。

Codonopsis Radix is a traditional tonic medicine commonly used in China,which has the effects of strengthening the spleen and tonifying the lung,as well as nourishing blood and engendering liquid.The chemical constituents of Codonopsis species are mainly polyacetylenes,alkaloids,phenylpropanoids,lignans,terpenoids and saponins,flavonoids,steroids,organic acids,saccharides,and so on.Modern pharmacological studies showed that Codonopsis Radix also has a variety of pharmacological effects such as enhancing body immunity,protecting gastrointestinal mucosa and resisting ulcers,promoting hematopoietic function,regulating blood sugar,and delaying aging.In this paper,the chemical constituents of Codonopsis species and the pharmacological effects of Codonopsis Radix were summarized,and on this basis,the quality markers of Codonopsis Radix were analyzed.It was predicted that lobetyolin,tangshenoside I,codonopyrrolidium A,and the oligosaccharides were the possible Q-markers of Codonopsis Radix.This paper will provide scientific references for the quality evaluation and profound research and the development of Codonopsis Radix.