Control of CAR-T cell activity in space and time:the next level of anti-tumor action

In two recent papers published in Science,advanced synthetic biology techniques were used to overcome the limitations of chimeric antigen receptor(CAR)-T cell therapy:In one case,CAR-T cells were successfully introduced into and maintained in solid tumors,1 and in another approach,CAR-T cell proliferation and activation could be turned on and off in a time-dependent manner by drug administration.2 These approaches might improve therapy for a large number of solid malignancies.