摘要
Dear Editor,Aging results in higher susceptibility to age-related disease,especially cardiovascular disease,which has become a public health priority.1,2 Recent studies have progressively unraveled the critical role of vasculature as a gatekeeper of life-span and health-span.3 In this light,vascular rejuvenation is geroprotective.The circulating proteomic signature is tightly related to aging and aging-induced vascular diseases,4 but drugs targeting circulating proteins are not available.
基金
supported by the National Natural Science Foundation of China (82200437,81970426)
CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-1-003)
National Key Research and Development Program of China (2022YFC2703100)
Shanghai Clinical Research Center for Interventional Medicine (19MC1910300)
National High Level Hospital Clinical Research Funding 2022-PUMCH-B-098.
