Tumor-draining lymph node-derived tumor-specific memory CD8^(+)T cells:a key player in PD-1/PD-L1 immunotherapy

A new study by Huang et al.in Cell identified the presence of tumorspecific memory CD8^(+)T cells in tumor-draining lymph nodes(TdLNs)and confirmed the critical role of this population in PD-1/PD-L1 immune checkpoint therapy for cancer.I The work enriched our understanding of tumor-specific CD8^(+)T cell subsets and further refined the spatiotemporal mechanism of the antitumor effects of PD-1/PD-L1 immune checkpoint blockade(ICB).