Potential recombination between SARS-CoV-2 and MERSCoV:calls for the development of Pan-CoV vaccines

In a recent study published in Nature,Yan and colleagues demonstrated that NeoCoV,a potential MERS-CoV ancestor in bats,can use bat ACE2 as its entry receptor and that NeoCoV S pseudotyped virus,which contains a T510F mutation in the receptor-binding domain(RBD),enters cells expressing human ACE2(hACE2).1 The findings reveal a potential zoonotic threat that MERS-CoV could,during its evolution,be gaining the ability to use hACE2 as an entry receptor and,thus,could also coinfect ACE2-expressing cells with SARS-CoV-2.