非标记小分子药物靶点发现技术及其在中药研究中的应用

Label-free target discovery technology of small molecule drug and its application in traditional Chinese medicines

药物靶点的发现在药物研发中发挥着至关重要的作用,非标记的药物靶点发现技术因其无需改造药物小分子结构,能更真实反映小分子药物与靶点互作,成为药物靶点发现的新途径。中药(traditional Chinese medicines,TCMs)具有多成分、多靶点的特性,其作用靶点及机制的研究备受制约,鉴于非标记的药物靶点发现技术在TCMs化学成分靶点发现研究中的应用潜力,本文综述了非标记的药物靶点发现新技术及其在TCMs研究中的应用,为TCMs化学成分靶点的发现提供参考,为促进TCMs现代化的发展提供新思路。

The discovery of drug targets plays a crucial role in drug research.Accurate information of small molecule drug-protein interaction can be provided by label-free target discovery technology without any structural modification at the small molecule.So,the label-free drug target discovery technology had become the powerful tool to discover the targets of drugs.Due to the“multi-component and multi-target”characteristics of traditional Chinese medicines(TCMs),the research on its targets and mechanism had been restricted.Based on potential of the label-free target discovery technology in the research of TCMs,this paper summarized the label-free target discovery technology and its application in TCMs research.It will provide a reference for the discovery of targets of TCMs and a new view for promoting the modernization of TCMs.