糖酵解-脂肪酸代谢失衡调控的铁死亡在代谢性疾病中的研究进展

Research progress on ferroptosis regulated by glycolysis-fatty acid metabolism in metabolic diseases

在代谢性疾病中,活性氧累积及氧化应激与铁死亡密切相关。糖酵解-脂肪酸代谢失衡作为代谢性疾病关键调控方式,能够直接或间接参与铁死亡,影响其发生发展。而铁死亡是一种新型调节性细胞死亡方式,由铁依赖性脂肪酸过氧化物过度累积引发。其与糖酵解-脂肪酸代谢密切相关,在代谢性疾病中发挥重要作用。该调节性细胞死亡方式显著区别于其他程序性死亡方式,在细胞形态、标志性特征及机制等方面均有独特变化。本文首先阐明糖酵解及脂肪酸代谢失衡参与铁死亡发生的主要机制,并进一步综述铁死亡在肿瘤、2型糖尿病及类风湿关节炎等代谢性疾病中的研究进展,揭示糖酵解-脂肪酸代谢失衡与铁死亡异常的内在联系及其对代谢性疾病的影响,以期为代谢性疾病防治提供新策略。

In metabolic diseases,the accumulation of reactive oxygen species and oxidative stress are closely associated with ferroptosis.As a key regulatory factor,the imbalance between glycolysis and fatty acid metabolism can participate in ferroptosis directly or indirectly,thereby regulating the occurrence and development of various metabolic diseases.The essence of ferroptosis is a new regulatory cell death mode,which is caused by the excessive accumulation of iron-dependent lipid peroxide.It is closely related to glycolysis and fatty acid metabolism,which plays an important role in metabolic diseases.This regulatory cell death mode is significantly distinguished from other programmed cell death modes and has unique changes in cell morphology,symbolic characteristics and mechanisms.This paper first illustrates the main mechanism of glycolysis and fatty acid metabolism imbalance in the occurrence of ferroptosis,then reviews the research progress of ferroptosis in tumor,diabetes,rheumatoid arthritis and other metabolic diseases,and finally reveals the internal connection between glycolysis-fatty acid metabolism imbalance and ferroptosis,as well as its impacts on metabolic diseases,which provide new strategies for the prevention and treatment of metabolic diseases.