尼莫地平联合替罗非班对颅内动脉瘤患者双微导管技术介入栓塞治疗中的效果

Effect of Nimodipine Combined with Tirofiban in the Interventional Embolization Treatment of Intracranial Aneurysm Patients with Double Microcatheter Technique

目的分析颅内动脉瘤患者双微导管技术介入栓塞治疗中使用替罗非班以及尼莫地平的作用。方法随机选择2019年1月—2021年1月漳州市第二医院收治的60例颅内动脉瘤患者为研究对象。全部患者在进入医院后均开展双微导管技术介入栓塞治疗,通过随机摸红蓝球方式分为两组,其中摸红球为常规组(30例),摸蓝球为研究组(30例)。予以常规组患者替罗非班治疗,予以研究组患者替罗非班以及尼莫地平治疗。对比用药前后两组患者凝血指标、大脑中动脉血流速度、神经功能缺损评分(NFI)、治疗效果、急性血栓事件出现情况。结果用药后,研究组活化部分凝血活酶时间长于常规组,血小板计数水平低于常规组,差异有统计学意义(P<0.05)。用药后,研究组大脑中动脉血流速度高于常规组,差异有统计学意义(P<0.05)。用药后,研究组NFI得分低于常规组,差异有统计学意义(P<0.05)。研究组与常规组治疗总有效率分别为93.33%、73.33%,差异有统计学意义(P<0.05)。研究组与常规组急性血栓事件出现率分别为0.00%、16.67%,差异无统计学意义(P>0.05)。结论颅内动脉瘤患者在双微导管介入栓塞治疗中使用替罗非班和尼莫地平,能够延长部分凝血酶活化时间,降低血小板水平,提升大脑中动脉血流速度,改善神经缺损程度,提高治疗效果,安全性良好。

Objective To analyze the effects of tirofiban and nimodipine in the interventional embolization treatment of patients with intracranial aneurysm by double microcatheter technique.Methods 60 patients with intracranial aneurysm admitted to Zhangzhou Second Hospital from January 2019 to January 2021 were randomly selected as the study objects.After entering the hospital,all patients received interventional embolization with double microcatheter technology,and were randomly divided into two groups by touching red and blue balls,of which the red ball was the conventional group(30 cases),and the blue ball was the research group(30 cases).The conventional group was treated with tirofiban,and the study group with Tirofiban and nimodipine.Blood clotting indexes,middle cerebral artery flow velocity,neurological deficit score(NFI),therapeutic effect and occurrence of acute thrombotic events were compared between the two groups before and after medication.Results After medication,the activated partial thrombin time in the study group was longer than that in the conventional group,and the platelet count level was lower than that in the conventional group,and the difference was statistically significant(P<0.05).After medication.The middle cerebral artery blood flow velocity in the study group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).After medication,the NFI score of the study group was lower than that of the conventional group,and the difference was statistically significant(P<0.05).The total effective rate of the study group and the conventional group was 93.33%and 73.33%,respectively,and the difference was statistically significant(P<0.05).The incidence rates of acute thrombotic events were 0.00%and 16.67%in the study group and the conventional group,respectively,and the difference was not statistically significant(P>0.05).Conclusion The use of tirofiban and nimodipine in doublemicrocatheter interventional embolization therapy for intracranial aneurysm patients can prolong the activation time of partial thrombin,reduce the level of platelet,improve the velocity of middle cerebral artery blood flow,improve the degree of nerve defect,improve the therapeutic effect.