布地格福吸入气雾剂治疗慢性阻塞性肺疾病急性加重期患者的效果分析

Effect of Budesonide Inhalation Aerosol on Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的 分析布地格福吸入气雾剂治疗慢性阻塞性肺疾病急性加重期患者的效果。方法 随机抽取2020年11月—2022年10月湖南省康复医院诊治的慢性阻塞性肺疾病急性加重期患者90例为研究对象,根据治疗方案不同分为对照组(n=45)、研究组(n=45),对照组予以布地奈德福莫特罗粉吸入剂治疗,研究组行布地格福吸入气雾剂治疗。组间比较治疗效果、不良反应发生率及肺功能、血气分析指标。结果 研究组治疗总有效率(100.00%)较对照组(86.67%)更高,差异有统计学意义(χ^(2)=4.464,P<0.05)。治疗后,研究组PaCO_(2)、心率、呼吸频率较对照组更低,PaO_(2)较对照组更高,FEV_(1)、FVC、FEV_(1)/FVC、6MWD较对照组更高,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 布地格福吸入气雾剂用于慢性阻塞性肺疾病急性加重期患者中,对提升治疗效果以及改善患者肺功能、血气分析指标,均有显著效果。

Objective To analyze the effect of Budesonide inhalation aerosol on patients with acute exacerbation of chronic obstructive pulmonary disease.Methods Ninety patients with acute exacerbation of chronic obstructive pulmonary disease diagnosed and treated in Hunan Rehabilitation Hospital from November 2020 to October 2022 were randomly selected as the objects of study.They were divided into control group(n=45)and study group(n=45)according to different treatment regimens.The control group was treated with budesonide formoterol powder inhalation,while the study group was treated with Budesonide inhalation aerosol.The treatment effect,incidence of adverse reactions,lung function and blood gas analysis index were compared between groups.Results The total effective rate of the study group was 100.00%,which was higher than 86.67%of the control group,the difference was statistically significant(χ^(2)=4.464,P<0.05).After treatment,PaCO_(2),heart rate and respiratory rate in the study group were lower than those in the control group,PaO_(2) was higher than that in the control group,FEV_(1),FVC,FEV_(1)/FVC,6MWD were higher than those in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion The application of Budesonide inhalation aerosol in patients with acute exacerbation of chronic obstructive pulmonary disease has a significant effect on improving the therapeutic effect,lung function,blood gas analysis indexes.