酸枣仁汤加味联合隔药灸对阴虚火旺证失眠的疗效及睡眠质量、生活质量的影响

Curative Effect of Modified Suanzaoren Decoction Combined with Herbpartitioned Moxibustion on Insomnia of Yin Deficiency and Hyperactivity of Fire Syndrome and Its Influence on Sleep Quality and Quality of Life

目的探讨酸枣仁汤加味联合隔药灸对阴虚火旺证失眠的疗效及睡眠质量、生活质量的影响。方法随机选取2020年5月—2022年3月福建省泉州市正骨医院收治的阴虚火旺证失眠患者80例为研究对象,采用随机数字表法分为对照组和观察组,各40例。对照组接受常规西药治疗,观察组接受酸枣仁汤加味联合隔药灸治疗。比较两组患者疗效、β-内啡肽(β-EP)、5-羟吲哚乙酸(5-HIAA)、5-羟色胺(5-HT)、睡眠质量、生活质量、不良反应情况。结果观察组总有效率高于对照组(95.00%vs 75.00%),差异有统计学意义(χ^(2)=6.274,P<0.05)。治疗前,两组β-EP、5-HIAA、5-HT指标比较,差异无统计学意义(P>0.05);治疗后,与对照组相比,观察组β-EP、5-HT水平更高,5-HIAA水平更低,差异有统计学意义(P<0.05)。治疗前,两组PSQI评分、SRSS评分、SF-36评分比较,差异无统计学意义(P>0.05);治疗后,与对照组相比,观察组PSQI评分、SRSS评分更低,SF-36评分更高,差异有统计学意义(P<0.05)。两组不良反应发生率比较(5.00%vs 7.50%),差异无统计学意义(P>0.05)。结论临床治疗阴虚火旺证失眠患者可应用酸枣仁汤加味联合隔药灸治疗,以更好地改善机体β-EP、5-HIAA、5-HT指标,提升睡眠和生活质量,安全高效。

Objective To explore the curative effect of modified Suanzaoren Decoction combined with herbpartitioned moxibustion on insomnia of yin deficiency and hyperactivity of fire,and the effect on sleep quality and quality of life.Methods 80 insomnia patients with yin deficiency and fire hyperactivity syndrome admitted to Quanzhou Zhenggu Hospital in Fujian Province from May 2020 to March 2022 were randomly selected as the research subjects.They were randomly divided into a control group and an observation group using a random number table method,with 40 cases in each group.The control group received conventional Western medicine treatment,while the observation group received modified Suanzaoren Decoction combined with herbpartitioned moxibustion treatment.Compared the treatment efficacy of two groups of patientsβendorphin(βEP),5hydroxyindoleacetic acid(5HIAA),5hydroxytryptamine(5HT),sleep quality,quality of life,and adverse reactions.Results The total effective rate of the observation group was higher than that of the control group(95.00%vs 75.00%),and the difference was statistically significant(χ^(2)=6.274,P<0.05).Before treatment,there was no statistically significant difference in the indicators ofβEP,5HIAA,and 5HT between the two groups(P>0.05);after treatment,compared with the control group,the observation group had higher levels ofβEP and 5HT,and lower levels of 5HIAA,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the PSQI score,SRSS score,and SF36 score between the two groups(P>0.05);after treatment,compared with the control group,the observation group had lower PSQI scores,SRSS scores,and higher SF36 scores,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(5.00%vs 7.50%)(P>0.05).Conclusion In clinical treatment of insomnia patients with yin deficiency and fire excess syndrome,the combination of sour jujube kernel decoction and herbal moxibustion can be used to better improve the body´sβEP,5HIAA,and 5HT indicators,improve sleep quality and quality of life,and be safe and efficient.