纤支镜组织病理联合免疫细胞化学在肺癌病理分型诊断中的应用价值研究

Study on the Application Value of Bronchoscopy Histopathology Combined with Immunocytochemistry in Pathological Diagnosis of Lung Cancer

目的:探究纤支镜组织病理联合免疫细胞化学在肺癌病理分型诊断中的应用价值,为临床治疗提供参考。方法:选取2019年8月—2021年7月灌云县人民医院接受病理检查肺部病变的63例患者作为研究对象,所有患者均行纤支镜组织病理检查,同时行免疫细胞化学检测。以常规病理活检为金标准,观察单独纤支镜组织病理诊断和纤支镜组织病理联合免疫细胞化学诊断结果与常规病理活检的差异性。结果:单独纤支镜组织病理诊断可分型49例,鳞癌、腺癌及小细胞癌诊断符合率分别为72.00%、73.33%及84.62%;联合行纤支镜组织病理和免疫细胞化学诊断可分型60例,鳞癌、腺癌及小细胞癌诊断符合率分别为92.00%、100.00%及100.00%;联合诊断鳞癌、腺癌及小细胞癌符合例数分别为23例、15例及13例,合计可分型诊断符合51例(96.23%),差异有统计学意义(χ^(2)=7.766,P<0.05)。结论:纤支镜组织病理联合免疫细胞化学行肺癌病理分型,诊断准确性较高,可为临床治疗提供重要参考。

Objective:To investigate the value of fibrinoscopic histopathology combined with immunocytochemistry in the diagnosis of lung cancer pathological staging.Methods:63 patients who underwent pathological examination of pulmonary lesions in hospitals from August 2019 to July 2021 were selected for the study,and all patients underwent histopathological examination by fibrinoscopy and immunocytochemical testing at the same time.The diagnostic coincidence rates of squamous cell carcinoma,adenocarcinoma and small cell carcinoma were 72.00%,73.33%and 84.62%respectively.Histopathological and immunocytochemical diagnosis of fiberoptic bronchoscope can be divided into 60 cases.The conventional pathological biopsy was used as the gold standard,and the discrepancy between the histopathological diagnosis by fibrinoscopy alone and the histopathological diagnosis by fibrinoscopy combined with immunocytochemistry and the conventional pathological biopsy was observed.Results:The histopathological diagnosis by fibrinoscopy alone could be staged in 49 cases,and the diagnostic compliance rates were 72.00%,73.33%and 84.62%for squamous carcinoma,adenocarcinoma and small cell carcinoma,respectively.Combined histopathological and immunocytochemical diagnosis by fibrinoscopy could be staged in 60 cases,and the diagnostic compliance rates were 92.00%,100.00%and 100.00%for squamous carcinoma,adenocarcinoma and small cell carcinoma,respectively.There were 23 cases,15 cases and 13 cases of squamous cell carcinoma,adenocarcinoma and small cell carcinoma,respectively,and 51 cases(96.23%)could be classified,the difference was statistically significant(χ^(2)=7.766,P<0.05).Conclusion:The combination of fibrobronchoscopy histopathology and immunocytochemistry in pathological classification of lung cancer has high diagnostic accuracy and can provide an important reference for clinical treatment.