花椒属植物中酰胺类成分的结构与功能研究进展

Research advance on structure and function of amides in Zanthoxylum plants

花椒属Zanthoxylum为芸香科Rutaceae植物,在我国有81种36变种。花椒属植物大多作为调味料,近年来国内外学者对其研究颇为深入,研究结果表明花椒属植物所特有的麻味来源于酰胺类化学成分,也确定酰胺类成分是发挥药理作用的重要物质基础,尤其在抗炎镇痛、麻醉等方面具有良好的效果。该文系统归纳了26种花椒属植物中已报道的123个酰胺类化学成分及其药理作用,为花椒属植物的临床应用、新药研发提供科学参考,也为其资源的可持续利用提供科学依据。

Zanthoxylum belongs to the Rutaceae family,and there are 81 Zanthoxylum species and 36 varieties in China.Most of the Zanthoxylum plants are used as culinary spice.In recent years,scholars in China and abroad have carried out in-depth research on Zanthoxylum plants,and found that the peculiar numbing sensation of Zanthoxylum plants originates from amides.It is also determined that amides are an important material basis for exerting pharmacological effects,especially in anti-inflammatory analgesia,anesthesia and other aspects.In this paper,123 amides in 26 Zanthoxylum plants and their pharmacological activity that have been reported were summarized,which provided scientific reference for the clinical application of Zanthoxylum plants and the research and development of new drugs,and also facilitated the sustainable development and utilization of Zanthoxylum plant resources.