甘精胰岛素与瑞格列奈联合治疗老年糖尿病的临床疗效分析

Clinical Analysis of Insulin Glargine Combined with Repaglinide in the Treatment of Senile Diabetes Mellitus

目的观察甘精胰岛素与瑞格列奈联合治疗老年糖尿病患者的临床疗效。方法选取2021年1—12月安丘市市立医院老年糖尿病患者100例,并随机分为两组,每组50例。研究组实施甘精胰岛素与瑞格列奈联合干预,对照组实施单独甘精胰岛素干预,统计分析两组患者临床疗效。结果治疗前,两组血糖相关指标比较,差异无统计学意义(P>0.05);治疗后,研究组FPG、2 hPG、HbA1c均低于对照组,差异有统计学意义(P<0.05);研究组血糖控制指数、胰岛素用量小于对照组,差异有统计学意义(P<0.05);两组预后低血糖发生率比较,差异无统计学意义(P>0.05)。结论老年糖尿病患者治疗中甘精胰岛素与瑞格列奈联合治疗的疗效较单独甘精胰岛素治疗更佳,可获得较好的血糖控制效果、减少胰岛素用量、降低低血糖不良反应发生率。

Objective To observe the clinical effect of insulin glargine combined with repaglinide in the treatment of senile diabetes.Methods A total of one hundred elderly diabetic patients in Anqiu Municipal Hospital from January to December 2021 were selected and randomly divided into two groups,with fifty cases in each group.The study group received combined intervention of insulin glargine and repaglinide,and the control group received single intervention of insulin glargine.The clinical efficacy of the two groups was statistically analyzed.Results There was no statistically significant difference in blood glucose related indexes between two groups before treatment(P>0.05).After treatment,FPG,2 hPG and HbA1c of the study group were lower than those of the control group,the difference was statistically significant(P<0.05).The glycemic control index and dosage of insulin of the study group were shorter than those of the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence index of prognostic hypoglycemia between two groups(P>0.05).Conclusion In the treatment of elderly patients with diabetes,the combined treatment of insulin glargine and repaglinide has better clinical efficacy than that of insulin glargine alone,it can achieve better blood glucose control effect,reduce the amount of insulin,and reduce the incidence of adverse reactions of hypoglycemia.