白细胞介素36在炎症性肠病中的研究进展

Research progress of interleukin-36 in inflammatory bowel disease

白细胞介素36(IL-36)作为IL-1超家族成员, 具有维持体内稳态和调节炎症反应的功能。最近研究表明IL-36在炎症性肠病(IBD)中发挥重要作用, 且在疾病发展的不同阶段对肠道炎症发挥复杂的调控作用。本文综述IL-36在肠道炎症中的作用及其在IBD靶向治疗中的研究进展。

Interleukin(IL)-36,a member of the IL-1 superfamily,has the function of maintaining homeostasis and regulating inflammation.Recent studies have shown that IL-36 plays an important role in inflammatory bowel disease(IBD),and plays a complex role in regulating intestinal inflammation at different stages of disease.This article reviews the roles of IL-36 in intestinal inflammation and the progress in targeted therapy of IBD.