2011-2019年我国腹泻住院患儿中G1P[8]型A组轮状病毒的流行病学和临床特征分析

Epidemiological and Clinical Characteristics of G1P[8]Group-A Rotavirus in Hospitalized Children with Diarrhea in China from 2011 to 2019

了解2011-2019年G1P[8]型A组轮状病毒(Group A rotavirus,RVA)在我国腹泻住院患儿中的流行病学和临床特征。收集2011年1月-2019年12月我国病毒性腹泻监测网络数据。监测网数据的采集和整理采用EpiData 3.0软件和Excel 2010,应用SPSS 26.0软件进行数据分析。2011-2019年共采集到我国5岁以下急性胃肠炎住院患儿标本共计47 386份,结果显示G1P[8]型RVA阳性率为1.98%(938/47 386),G1P[8]型RVA感染不具有明显的性别分布特征。G1P[8]型RVA的流行季节为秋冬季,夏季该基因型有小暴发的情况发生。G1P[8]型RVA住院患儿在腹泻严重程度(χ^(2)=0.177,P=0.915,P>0.05)与非G1P[8]型RVA住院患儿无明显差异,G1P[8]型RVA相对于非G1P[8]型RVA患儿在发热(χ^(2)=22.572,P=0,P<0.05)、皮疹、肺炎、败血症等并发症(χ^(2)=12.921,P=0,P<0.05)少且轻。2011-2019年我国G1P[8]型RVA流行趋势逐渐下降,季节高峰为秋冬季,夏季偶有暴发,G1P[8]型RVA发热等并发症较非G1P[8]型RVA轻。本研究为RVA疫苗候选毒株选择提供数据参考,为G1P[8]型RVA防控和治疗提供基础数据支持。

To understand the epidemiological and clinical characteristics of G1P[8]group-A rotavirus(RVA)in hospitalized children with diarrhea in China from 2011 to 2019.Data from the Viral Diarrhea Surveillance Network in China from January 2011 to December 2019 were collected.EpiData 3.0 and Excel TM 2010 were used for the collection and sorting of data,and SPSS 26.0 was used for data analyses.A total of 47,386 samples from hospitalized children(age<5 years)with acute gastroenteritis were collected from 2011 to 2019.The positive rate of G1P[8]RVA was 1.98%(938/47386).GIP[8]RVA infection did not have obvious distribution between boys and girls.The epidemic season of GIP[8]RVA infection was autumn and winter,and there was a small outbreak of this genotype in the summer.There was no significant difference in severity between hospitalized children with G1P[8]RVA or with non G1P[8]RVA(x^(2)=0.177,P=0.915,P>0.05),The symptoms of G1P[8]RVA are lighter than those of non G1P[8]RVA such as fever(x^(2)=22.572,P=0,P<0.05)as well as rash,pneumonia,and sepsis(x^(2)=12.921,P=0,P<0.05).From 2011 to 2019,the epidemic trend of G1P[8]RVA infection in China decreased gradually.The seasonal peak was in autumn and winter,with occasional outbreaks in the summer.The symptoms of G1P[8]RVA infection were less severe than those of non G1P[8]RVA.Our study provides:(i)data support for the prevention,control and treatment of G1P[8]RVA;(ii)data reference for selection of candidate strains of a G1P[8]RVA vaccine.