摘要
病毒在感染细胞后,病毒借助细胞内质网(Endoplasmic reticulum, ER)进行病毒基因组的部分蛋白表达,造成内质网压力过载。内质网会通过非折叠蛋白反应(Unfolded protein response, UPR)维持其自身的稳态,UPR包括PERK、IRE1、ATF6信号三种信号途径,并且会通过不同机制调控病毒的复制。在本综述中,简要综述了由病毒所介导的UPR对于抗病毒天然免疫反应的调控作用,并且本综述也对几种冠状病毒通过诱导UPR调控天然免疫反应进行了简要概述,以期为了解病毒复制提供参考。
After virus infection,the viral genome is translated through the host endoplasmic reticulum(ER),which causes ER pressure overload.The ER induces unfolded protein response(UPR)to maintain its own homeostasis.UPR involves three signaling pathways,named PERK,IREl,and ATF6.These pathways regulate viral replication by different mechanisms.In this review,the regulatory effect of virus-mediated UPR on the host antiviral innate immune response is reviewed briefly.Also,we briefly summarizes the regulation of the innate immune response by several coronaviruses-induced UPR,in order to provide a reference for understand the virus replication.
作者
郑亮
王宏宇
Matthew KAY
高振秋
曹宏伟
耿荣庆
陈志宝
吴志军
张华
ZHENG Liang;WANG Hongyu;KAY Matthew;GAO Zhenqiu;CAO Hongwei;GENG Rongqing;CHEN Zhibao;WU Zhijun;ZHANG Hua(School of Pharmacy,Yancheng Teachers University,Yancheng 224007,China;College of Animal Science and Veterinary Medicine,Heilongjiang Bayi AgricμLtural University,Daqing 163319,China;College of Life Science and Technology,Heilongjiang Ba Yi Agricultural University,Daqing 163319,China;Binhai College of Agriculture,Guangdong Ocean University,Zhanjiang 524088,China;Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials,Yancheng 224007,China)
出处
《病毒学报》
CAS
CSCD
北大核心
2023年第3期868-876,共9页
Chinese Journal of Virology
基金
国家自然科学基金面上项目(项目号:32272995),题目:PEDV S蛋白内质网驻留信号(ERRS)在病毒诱导应激颗粒形成过程中的作用机制
江苏省肿瘤靶向纳米诊疗材料工程研究中心开放基金资助(项目号:JETNM202207),题目:负载PEDV S1蛋白磷酸钙纳米颗粒的构建及其抗宫颈癌活性的研究
江苏省盐土生物资源研究重点实验室开放课题(项目号:JKLBS2020005),题目:WH1fungin佐剂优化的肝癌细胞疫苗制备及抗肝癌作用研究。
关键词
非折叠蛋白反应
天然免疫
冠状病毒
Unfolded protein response
Innate immunity response
Coronavirus
