钌催化喹唑啉酮与碳酸亚乙烯酯的C—H[4+2]环化反应

Ruthenium-Catalyzed C-H[4+2]Annulation of Quinazolinones with Vinylene Carbonate

过渡金属催化下的惰性C-H环化反应作为有机化学领域的一种高效策略,可构筑一系列碳环及杂环分子骨架.近年来,化学家们利用碳酸亚乙烯酯作为碳合成子,并借助其特殊的结构、无氧化剂的催化体系以及碳酸为唯一副产物的优势,为构建非取代杂环化合物提供了一种新思路.提出一类在钌催化下,喹唑啉酮与碳酸亚乙烯酯发生的C-H[4+2]环化反应,并以良好的收率获得2,3-稠合喹唑啉酮衍生物.

Transition metal-catalyzed inert C-H annulation reaction,an efficient strategy in the field of organic chemistry,is capable of constructing a series of carbon-or heterocycle molecules.Very recently,organic chemists have commenced to employ vinylene carbonate as a carbon synthon for the efficient construction of non-substituted heterocyclic compounds,which benefits with the enriched product structure,quite simple and concise reaction system,and the sole carbonic acid as by-product.A new type of C-H[4+2]cyclization reaction of quinazolinone with ethylene carbonate catalyzed by ruthenium is proposed,and 2,3-fused quinazolinone derivatives are obtained with good yields.