肿瘤患者退出药物临床试验后心理体验的质性研究

Qualitative Study on the Psychological Experience of Cancer Patients after Withdrawing from Drug Clinical Trials

目的了解癌症患者退出药物临床试验后的真实心理感受,为临床医护人员对退出药物临床试验后过渡期的患者进行个性化的护理提供借鉴。方法采用描述性现象学的方法,通过立意抽样法选取山东省某三甲医院肿瘤内科参与药物临床试验后退出的11例受试者进行半结构式深入访谈,使用Colaizzi七步分析法进行分析、整理,提炼主题。结果肿瘤患者退出药物临床试验后心理体验可归纳为4个主题:参加临床试验的受益、退出临床试验的失落、对未来治疗的态度、期望得到的帮助。结论肿瘤患者退出药物临床试验后,面临巨大的心理压力,需要深切的情感支持和人文关怀,护理人员应采取个性化的护理措施,满足受试者心理需求的特殊性问题,以帮助患者顺利渡过退出阶段并进入到后续的治疗当中。

Objective:To understand the real psychological feelings of cancer patients after withdrawing from drug clinical trials,and provide reference for clinical healthcare professionals to serve personalized care for patients in the transitional period after withdrawing from drug clinical trials.Methods:With the descriptive phenomenology method,11 subjects who withdrew from drug clinical trials in the oncology department of a tertiary hospital in Shandong Province were selected by intentional sampling method to conduct semi-structured in-depth interviews.Colaizzi seven-step analysis method was used to analyze and sort out records,and refine themes.Results:The psychological experiences of cancer patients after withdrawing from drug clinical trials were summarized into four themes:benefits of participating in clinical trials,losses of withdrawing from clinical trials,attitudes towards future treatment,and expectations of receiving help.Conclusion:Cancer patients face great psychological pressure after withdrawing from drug clinical trials and require deep emotional support and humanistic care.Nursing staff should take personalized care measures to meet the special problems of patients psychological needs,so as to help patients smoothly pass through the withdrawal stage and enter subsequent treatment.