In(OTf)_(3)催化双亚胺分子间环化反应合成吖啶

In(OTf)_(3)-catalyzed Intermolecular[3+2+1]Cyclization of Two Imine Units

使用廉价易得的亚胺化合物在In(OTf)_(3)与氧化剂串联条件下进行[3+2+1]环化反应,实现了亚胺分子的新化学转化模式,最终以良好至优秀的产率合成了23种结构新颖的吖啶衍生物.该方法条件简单,具有良好的底物适用性与基团兼容性,为在光电材料领域广泛应用的吖啶化合物的合成提供了一种新途径.

A facile In(OTf)_(3)-catalyzed[3+2+1]annulation reaction between imine units was developed,which represents a novel chemical transformation with imines.In this conversion,23 kinds of structurally diversified acridine derivatives were rapidly obtained in moderate to excellent yields.This protocol features broad substrate scope and excellent functional groups tolerance,giving a new platform for preparing acridines widely used in the program of photoelectric materials.