儿科住院患者流感病毒合并革兰阳性菌感染临床特征与治疗转归的分析

Analysis of clinical features and treatment outcomes of influenza virus i nfection with gram-positive bacteria in pediatric inpatients

目的:分析儿科住院患者流感病毒合并革兰阳性菌感染的临床特征与治疗转归情况。方法:回顾性选取2020年1月至2022年12月期间于我院儿科住院治疗的流感病毒未合并革兰阳性菌(G+)感染患者59例作为对照组,取同期收入的流感病毒合并G+感染患者59例作为研究组,分析两组患者的临床特征与治疗转归情况。结果:分析两组的临床特征发现,研究组的1年内流感疫苗接种率、年龄、肺炎球菌疫苗接种率与对照组相比均明显更低,P<0.05;研究组的基础疾病率、高热时间、使用抗菌药占比、神经氨酸酶抑制剂首次使用时间>48 h占比以及住院时间均高于对照组,P<0.05。研究组所有患者均接受了神经氨酸酶抑制剂、敏感性抗生素治疗,均未出现严重不良反应或并发症,无患者死亡,预后转归良好。结论:流感病毒合并革兰阳性菌感染会导致病情加重,增加治疗难度,临床需及时分析患者的临床特征,明确耐药情况,选择高敏感性抗生素及相关药物开展治疗,以促进患者的病情转归。

Objective:To analyze the clinical characteristics and treatment outcomes of influenza virus infection with gram-positive bacteria in pediatric inpatients.Methods:Fifty-nine cases of influenza virus patients not infected with gram-positive bacteria(G+)who were hospitalized in our hospital from January 2020 to December 2022 were selected as the control group,and 59 cases of influenza virus patients with G+infection were selected as the study group.Clinical characteristics and treatment outcomes of the two groups of patients were analyzed.Results:The analysis of clinical characteristics of the two groups showed that the influenza vaccine coverage rate,age,pneumococcal vaccine coverage rate in 1 year in the study group were significantly lower than that in the control group,P<0.05;The rate of underlying disease,time of high fever,proportion of antibiotic use,proportion of first use time>48 h of neuraminidase inhibitor and length of hospital stay in the study group were higher than those in the control group,P<0.05.All patients in the study group were treated with neuraminidase inhibitors and sensitive antibiotics,and no serious adverse reactions or complications occurred.No patients died,and the prognosis was good.Conclusion:Influenza virus infection with gram-positive bacteria can aggravate the illness and increase the difficulty of treatment.Clinical analysis of the clinical characteristics of patients should be timely,drug resistance should be clarified,and highly sensitive antibiotics and related drugs should be selected for treatment,so as to promote the prognosis of patients.