免疫抑制剂用药依从性管理对肾移植受者移植肾功能的影响

Effect of compliance management of immunosuppressive drugs on function of transplanted kidney in recipients

目的探讨免疫抑制剂用药依从性管理对肾移植受者移植肾功能的影响。方法选取肾移植受者110例,随机分为观察组55例和对照组55例。根据随访结果,最终观察组纳入55例,对照组纳入54例。对照组采取常规随访模式;观察组实施为期半年的定期随访,并进行用药依从性教育和管理。采用Morisky问卷进行依从性调查,比较2组患者血药浓度、肌酐、估算肾小球滤过率、急性排斥发生情况。结果观察组依从性好患者比率高于对照组,差异有统计学意义(P<0.05)。观察组血药浓度不达标发生率低于对照组,差异有统计学意义(P<0.05)。在术后6个月,2组血肌酐、估算肾小球滤过率比较,差异有统计学意义(P<0.05)。2组急性排斥反应发生率比较,差异无统计学意义(P>0.05)。结论加强肾移植受者用药依从性管理对保持良好的移植肾功能有重要作用。

Objective To investigate the effect of compliance management of immunosuppressive drugs on renal function of transplanted kidney in recipients.Methods A total of 110 kidney transplant recipients were randomly divided into observation group(55 cases)and control group(55 cases).According to the follow-up results,55 cases were included in observation group and 54 cases in control group.The control group was followed up conventionally,and the observation group was followed up regularly for half a year,and medication compliance education and management were carried out.Morisky questionnaire was used to investigate compliance,and blood drug concentration,creatinine,estimated glomerular filtration rate and acute rejection were compared between the two groups.Results The proportion of patients with good compliance in the observation group was significantly higher than that in the control group(P<0.05).The incidence of substandard blood concentration in the observation group was significantly lower than that in the control group(P<0.05).At 6 months after surgery,there were statistically significant differences in serum creatinine and estimated glomerular filtration rate between the two groups(P<0.05).There was no significant difference in the incidence of acute rejection between the two groups(P>0.05).Conclusion It is important to strengthen medication compliance management of renal transplant recipients to maintain good renal function of kidney transplantation.