乙醛脱氢酶1A2在神经系统疾病中的研究进展

Research progress of aldehyde dehydrogenase 1A2 in nervous system diseases

乙醛脱氢酶1A2(ALDH1A2)是乙醛脱氢酶超家族成员之一,是一种存在于胞质内并广泛参与体内醛类物质氧化的醛类氧化酶。ALDH1A2是视黄酸合成的重要调节酶,其可能通过视黄酸合成减轻神经性炎症,参与调节内源性神经干细胞增殖和分化,对神经保护具有重要意义。ALDH1A2与神经系统相关疾病有关,包括阿尔茨海默病、肌萎缩侧索硬化症、神经管缺陷、脑肿瘤(如胶质母细胞瘤)等。因此,研究ALDH1A2基因及激活ALDH1A2将为相关神经系统疾病的治疗提供新的思路。

ALDH1A2,a member of the aldehyde dehydrogenase superfamily,is an aldehyde oxidase existing in cytoplasm and widely involved in the oxidation of aldehydes in vivo.ALDH1A2 is an important regulator of retinoic acid synthesis.ALDH1A2 may reduce neuroinflammation and participate in regulating the proliferation and differentiation of endogenous neural stem cells through this pathway,which is of great significance to the research of neuroprotection.A large number of studies have confirmed that ALDH1A2 is related to nervous system-related diseases,including Alzheimer's disease,amyotrophic lateral sclerosis,neural tube defects,brain tumors such as glioblastoma,etc.Therefore,the study of ALDH1A2 gene and activation of ALDH1A2 will provide new ideas for the treatment of related nervous system diseases.