水凝胶间隔器在妇科恶性肿瘤近距离治疗中的应用进展

Research progress on the application of hydrogel spacer in brachytherapy for gynecological tumors

放射治疗是妇科恶性肿瘤治疗的重要方式,尽管近些年一些新技术或新措施提高肿瘤控制率的同时可以减少放疗不良反应,但是事实证明,由于某些关键器官位置十分靠近肿瘤,放疗不良反应仍然是一个重大问题。新型材料生物水凝胶作为器官间隔器,为减少放疗不良反应提供了一种全新的方法。本文从水凝胶间隔器的特征、适宜人群、注射方式、间隔距离与剂量效应、临床益处与成本效益等多个方面,论述了生物水凝胶器官间隔器在妇科恶性肿瘤近距离治疗中的应用进展。

Radiotherapy is an important treatment of gynecological tumors.Although novel techniques or measures in recemy years have improved the tumor control rate and reduced radiation toxicity,radiation toxicity remains a major problem due to the location of some key organs adjacent to the tumor.A new material-hydrogel,as an organ spacer,provides a new method to reduce the radiotherapy toxicity.In this article,the application of hydrogel as an organ spacer in brachytherapy for gynecological tumors was reviewed from the aspects of hydrogel characteristics,suitable population,mode of injection,interval distance and dose effect,clinical benefits and cost effectiveness,etc.