摘要
放射治疗是恶性肿瘤的主要治疗手段之一, 能有效杀死癌细胞, 提高患者存活率。然而, 肿瘤细胞放疗抗性的产生很大程度上降低了放射治疗的疗效, 对其抵抗机制及疗法的探索具有重大意义。铁死亡作为一种新发现的细胞程序性死亡方式, 已有大量研究表明铁死亡与肿瘤放疗敏感性之间关系密切, 其机制涉及脂质活性氧堆积、谷胱甘肽代谢及铁代谢等。并且有报道指出铁死亡诱导剂可有效协同放疗增敏, 进一步促进肿瘤预后。本文围绕相关机制及研究进展进行综述, 并对这一领域未来的发展方向进行讨论, 以期为基于肿瘤放射治疗的临床试验及机制研究提供帮助。
As one of the most effective treatments for cancer,radiotherapy(RT)can eliminate the tumor cells and improve the survival rate of cancer patients.However,radiation resistance of tumor cells remarkably reduces the efficacy of RT.Therefore,it is significant to investigate the resistance mechanism and explore corresponding therapy for cancer.Ferroptosis is a novel mode of programmed cell death.Numerous studies have indicated an intimate connection between ferroptosis and tumor radiosensitivity.The mechanism involves lipid reactive oxygen species accumulation,glutathione metabolism and iron metabolism.It has been reported that ferroptosis inducers can act effectively and synergistically with RT,promote radiosensitivity and further improve tumor prognosis.In this article,relevant mechanisms and research progress were reviewed,and the future development direction of this field was discussed,aiming to provide reference for clinical trials and mechanism research of RT for malignant tumors.
作者
林苇
吴亚东
Lin Wei;Wu Yadong(School of Stomatology,Guizhou Medical University,Department of oral and maxillofacial surgery,Affiliated Stomatological Hospital,Guizhou Medical University,Guiyang 550000,China)
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2023年第6期572-576,共5页
Chinese Journal of Radiation Oncology
基金
国家自然科学基金(82060498)。
关键词
铁死亡
肿瘤
恶性
放射疗法
辐射敏感性
协同治疗
Ferroptosis
Neoplasms,malignant
Radiotherapy
Radiosensitivity
Synergistic therapy