铁死亡在恶性肿瘤放疗敏感性中的研究进展

Research progress on ferroptosis in radiosensitivity of malignant tumors

放射治疗是恶性肿瘤的主要治疗手段之一, 能有效杀死癌细胞, 提高患者存活率。然而, 肿瘤细胞放疗抗性的产生很大程度上降低了放射治疗的疗效, 对其抵抗机制及疗法的探索具有重大意义。铁死亡作为一种新发现的细胞程序性死亡方式, 已有大量研究表明铁死亡与肿瘤放疗敏感性之间关系密切, 其机制涉及脂质活性氧堆积、谷胱甘肽代谢及铁代谢等。并且有报道指出铁死亡诱导剂可有效协同放疗增敏, 进一步促进肿瘤预后。本文围绕相关机制及研究进展进行综述, 并对这一领域未来的发展方向进行讨论, 以期为基于肿瘤放射治疗的临床试验及机制研究提供帮助。

As one of the most effective treatments for cancer,radiotherapy(RT)can eliminate the tumor cells and improve the survival rate of cancer patients.However,radiation resistance of tumor cells remarkably reduces the efficacy of RT.Therefore,it is significant to investigate the resistance mechanism and explore corresponding therapy for cancer.Ferroptosis is a novel mode of programmed cell death.Numerous studies have indicated an intimate connection between ferroptosis and tumor radiosensitivity.The mechanism involves lipid reactive oxygen species accumulation,glutathione metabolism and iron metabolism.It has been reported that ferroptosis inducers can act effectively and synergistically with RT,promote radiosensitivity and further improve tumor prognosis.In this article,relevant mechanisms and research progress were reviewed,and the future development direction of this field was discussed,aiming to provide reference for clinical trials and mechanism research of RT for malignant tumors.