高压氧辅助治疗突发性聋的疗效分析

Analysis of therapeutic effects of hyperbaric oxygen therapy on sudden deafness

目的探讨高压氧作为辅助治疗对突发性聋疗效的影响。方法分析2019年12月至2022年12月在中国航天科工集团七三一医院耳鼻咽喉科就诊的突发性聋患者120例,随机分为对照组(57例)和高压氧组(63例),对照组应用常规药物治疗,7 d为1个疗程;高压氧组采用药物加高压氧治疗,每次治疗100 min,7 d为1个疗程,对比两组疗效。结果高压氧组有效率为90.5%(57/63),对照组有效率为84.2%(48/57),两组间差异有统计学意义(χ^(2)=6.72,P<0.05);其中听力损失<60 dB HL的患者,高压氧组有效率为93.9%(31/33),对照组有效率为93.3%(28/30),两组间差异无统计学意义(χ^(2)=2.13,P>0.05);听力损失≥60 dB HL的患者,高压氧组有效率为86.7%(26/30),对照组有效率为74.1%(20/27),两组间差异有统计学意义(χ^(2)=8.48,P<0.05)。病程<14 d内就诊的患者,高压氧组有效率为92.0%(46/50),对照组有效率为87.5%(42/48),两组间差异有统计学意义(χ^(2)=6.12,P<0.05);病程≥14 d的患者,高压氧组有效率为84.6%(11/13),对照组有效率为66.7%(6/9),两组间差异有统计学意义(χ^(2)=9.13,P<0.05)。结论对于听力损失较重及病程较长的患者,高压氧作为辅助治疗,是一种有效可行的方法。

Objective To investigate the effects of hyperbaric oxygen as an assistant therapy on sudden deafness.Methods 120 patients with sudden deafness in the Department of Otorhinolaryngology,No.731 Hospital of China Aerospace Science and Industry Corp from December 2019 to December 2022 were analyzed.They were randomly divided into hyperbaric oxygen group(n=57)and control group(n=63),and the control group was treated with conventional drug treatment for 7 days.The hyperbaric oxygen group was treated with drugs and hyperbaric oxygen for 7 days,100 minutes each day.The efficacy of the two groups was compared.Results The overall effective rate of hyperbaric oxygen group was 90.5%(57/63),and that of the control group was 84.2%(48/57),and the difference between the two groups was statistically significant(χ^(2)=6.72,P<0.05).Among the patients with hearing loss<60 dB HL,the effective rate of the hyperbaric oxygen group was 93.9%(31/33),and the effective rate of the control group was 93.3%(28/30),and the difference between the two groups was not statistically significant(χ^(2)=2.13,P>0.05).In patients with hearing loss≥60 dB HL,the effective rate was 86.7%(26/30)in the hyperbaric oxygen group and 74.1%(20/27)in the control group,and the difference between the two groups was statistically significant(χ^(2)=8.48,P<0.05);In patients with course of disease<14 days,the effective rate of the hyperbaric oxygen group was 92.0%(46/50)and the effective rate of the control group was 87.5%(42/48),and the difference between the two groups was statistically significant(χ^(2)=6.12,P<0.05).In patients with course of disease≥14 days,the effective rate of hyperbaric oxygen group was 84.6%(11/13)and that of the control group was 66.7%(6/9),and the difference between the two groups was statistically significant(χ^(2)=9.13,P<0.05).Conclusions Hyperbaric oxygen is an effective treatment for patients with severe hearing loss and long course of disease.