基于空间医学理论应用小小正坤散治疗小儿感染后脾虚综合征60例临床观察

Clinical observation on 60 cases of pediatric spleen deficiency syndrome after infection treated with Xiaoxiao Zhengkun San(小小正坤散)based on spatial medicine theory

目的 观察基于空间医学理论应用小小正坤散治疗小儿感染后脾虚综合征的临床疗效。方法 选取2021年1月至2022年1月南宁市中医医院儿科门诊就诊的感染后脾虚综合征患儿120例,按随机数字表法分为对照组和治疗组,各60例。对照组予双歧杆菌乳杆菌三联活菌片口服,治疗组予小小正坤散治疗,2组均连续治疗1个月,并随访3个月后统计临床疗效。结果 对照组总有效率为83.33%(50/60),治疗组为95.00%(57/60),2组比较,差异有统计学意义(P<0.05)。治疗前2组中医主、次症积分和总积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组主、次症积分和总积分较治疗前均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前2组血清免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、C3、C4水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组血清IgA、IgM、IgG、C3、C4水平均显著升高,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组升高更显著(P<0.05)。对照组不良反应发生率为1.67%(1/60),治疗组为3.34%(2/60),2组比较,差异无统计学意义(P>0.05)。2组治疗结束后随访3个月,治疗组复发率为5.26%(3/57),低于对照组的20.00%(10/50),2组比较,差异有统计学意义(P<0.05)。结论 基于空间医学理论应用小小正坤散治疗感染后脾虚综合征患儿疗效确切,不仅能有效缓解患儿的临床症状、体征,提高机体免疫力,降低复发率,而且不良反应小,值得临床推广应用。

Objective To observe the clinical efficacy of Xiaoxiao Zhengkun San(小小正坤散)based on spa-tial medicine theory in treating pediatric spleen deficiency syndrome after infection.Methods 120 cases of pediat-ric spleen deficiency syndrome after infection treated in the Pediatrics Department of Nanning Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were selected and divided into a control group and a treatment group with a random number table,with 60 cases in each group.The control group was given oral administration of Bifidobacterium and Lactobacillus triple live bacteria tablets,while the treatment group was given Xiaoxiao Zhengkun San for continuous treatment for one month.After 3 months of follow-up,the clinical efficacy was statisti-cally analyzed.Results The total effective rate in the control group was 83.33%(50/60),while that in the treat-ment group was 95.00%(57/60).There was a statistically significant difference between the two groups(P<0.05).There was no statistically significant difference in the main and secondary symptom scores and the total score between the two groups before treatment(P>0.05),indicating comparability.After treatment,the main and secondary symptom scores and the total score in both groups decreased significantly compared with before treatment(P<0.05).The treatment group showed a more significant decrease(P<0.05)than the control group.There was no statistically significant difference in the levels of serum immunoglobulin(Ig)A,IgM,IgG,C3,and C between the two groups before treatment(P>0.05),indicating comparability.After treatment,the levels of serum IgA,IgM,IgG,C3,and C4 in both groups increased significantly compared with before treatment(P<0.05),and the treatment group showed a more significant increase(P<0.05)than the control group.The incidence of adverse reactions in the control group was 1.67%(1/60),while that in the treatment group was 3.34%(2/60).There was no statistically significant difference between the two groups(P>0.05).After a 3-month follow-up after the end of treatment,the recurrence rate in the treatment group was 5.26%(3/57),which was lower than the 20.00%(10/50)in the control group.There was a statistically significant difference between the two groups(P<0.05).ConclusioXniaoxiao Zhengkun San based on spatial medicine theory is effective in treating pediatric spleen deficiency syndrome after infection.It can not only effectively relieve the clinical symptoms and signs of the patients,improve their immunity,and reduce the recurrence rate,but also has fewer adverse reactions.It is worth clinical promoting and application.