正己烷体内外诱导毒性效应的机制研究进展

Progress on the mechanism of n-hexane induced toxic effects in vitro and in vivo

正己烷是被广泛应用的一种有机溶剂,慢性正己烷中毒为我国主要的职业中毒之一。特别是周围神经系统远端粗纤维的轴索和髓鞘病变,可能由正己烷在人体内的中间代谢产物2,5-己二酮(2,5-HD)引起。正己烷不仅对神经系统有毒性作用,且有肝、肾和生殖性。本文以正己烷中毒性神经病变的机制研究进展进行综述。

Hexane is a widely used organic solvent in industry,and chronic hexane poisoning is the main occupational toxic lesion in China.In particular,axonal and myelin lesions in the distal thick fibers of the peripheral nervous system may be caused by 2,5-hexanedione(2,5-HD),an intermediate metabolite of n-hexane in humans.Hexane has toxic effects not only on the nervous system but also on the liver,kidneys,and reproductive organs.In this paper,we review the progress of research on the mechanism of n-hexane toxic neuropathy.