脂质蓄积指数与中国成年人高血压关系的meta分析

Meta analysis of correlation between lipid accumulation product and hypertension in Chinese adults

目的·探讨脂质蓄积指数(lipid accumulation product,LAP)与中国成年人高血压的关系。方法·通过检索英文数据库PubMed、Web of Science,中文数据库中国知网、万方数据知识服务平台,搜集从建库到2022年8月中国成年人LAP与高血压相关研究。由2位研究人员根据纳入和排除标准分别独立地对所有检索到的文献进行筛选,并使用JBI(Joanna Briggs Institute)诊断性研究量表对研究人群选择、可比性、暴露评价和结果等方面进行文献质量评估。对纳入的文献提取样本量、性别、灵敏度、特异度等信息,并使用Stata 16.0软件进行meta分析。结果·共纳入6篇文献,其中英文文献5篇,中文文献1篇。纳入文献的JBI偏倚评分为14~17分,均大于总分的70%,认为偏倚较小。纳入样本总数48329例,其中高血压患者15746例。Meta分析结果显示,在总人群中,LAP预测高血压的灵敏度为0.50(95%CI 0.35~0.64),特异度为0.78(95%CI 0.66~0.86);在女性中灵敏度为0.48(95%CI 0.32~0.64),特异度为0.77(95%CI 0.64~0.86);在男性中灵敏度为0.56(95%CI 0.39~0.72),特异度为0.64(95%CI 0.49~0.77)。纳入的总体人群综合受试者操作特征曲线(summary receiver operator characteristic curve,SROC曲线)下面积为0.70(95%CI 0.66~0.74),表明LAP和高血压存在一定的相关性。结论·在中国成年人群中,LAP与高血压有一定关联性。

Objective·To explore the correlation between lipid accumulation product(LAP)and hypertension in Chinese adults.Methods·By searching the English literature databases including PubMed and Web of Science,and the Chinese literature databases including CNKI and WanFang Data Knowledge Service Platform database,the earliest literature related to LAP and hypertension in Chinese adults that could be retrieved from databases establishment to August 2022.Two researchers independently screened all the retrieved literature according to the inclusion and exclusion criteria,and used the diagnostic research scale developed by Joanna Briggs Institute(JBI)to evaluate the literature quality of the selection,comparability,exposure evaluation and results of the study population.The sample size,gender,sensitivity,specificity and other information were extracted from the included literature.Stata 16.0 software was used for meta-analysis.Results·A total of 6 articles were included,including five in English and one in Chinese.The JBI bias scores of the included articles ranged from 14 to 17 points,all of which were greater than 70% of the total score,so the biases could be considered small.The total number of samples included was 48329,including 15746 patients with hypertension.The results of meta-analysis showed that in the total population,the sensitivity of LAP in predicting hypertension was 0.50(95%CI 0.35‒0.64),and the specificity was 0.78(95% CI 0.66‒0.86);In women,the sensitivity was 0.48(95% CI 0.32‒0.64),and the specificity was 0.77(95% CI 0.64‒0.86);In males,the sensitivity was 0.56(95% CI 0.39‒0.72),and the specificity was 0.64(95% CI 0.49‒0.77).The area under the summary receiver operator characteristic curve(SROC curve)of the total population included was 0.70(95%CI 0.66‒0.74),indicating that there was a certain correlation between LAP and hypertension.Conclusion·In Chinese adult population,LAP is associated with hypertension to a certain extent.