PM2.5对帕金森病的影响及饮食干预研究进展

Recent advance in effect and dietary intervention of PM2.5 on Parkinson's disease

帕金森病(PD)是全球第二大神经退行性疾病,主要临床特征为震颤、强直和运动迟缓。细颗粒物(PM2.5)是直径≤2.5µm的空气中颗粒物,流行病学研究显示PM2.5与PD的发病相关,短期和长期暴露于PM2.5都会增加PD的患病风险,但目前相关研究较少,具体机制仍不清楚。本文围绕PM2.5与PD的流行病学研究、作用机制及饮食干预策略等方面的研究进展进行综述。

Parkinson's disease(PD)is the second largest neurodegeneration disease in the world,characterized by tremors,rigidity and bradykinesia.Fine particulate matter(PM2.5)is a kind of airborne particulate matters whose diameter≤2.5µm.Epidemiological studies have shown that PM2.5 is associated with PD,and both short-term and long-term exposures to PM2.5 can increase PD risk.However,few relevant studies and still unclear mechanism are noted;therefore,this article reviews the epidemiological studies,mechanism and dietary intervention strategies of PM2.5 and PD.