HER-2阳性浸润性乳腺癌患者MRI影像多参数特征分析

Multi-Parameter Analysis of MRI Images in Patients with Invasive Breast Cancer with Positive HER-2

目的探讨HER-2阳性乳腺癌患者MRI影像多参数的特征。方法回顾性分析2019年1月至2020年11月我院经病理证实的52例浸润性乳腺癌患者的MRI影像资料,分析52例患者MRI图像征象(分叶、坏死、毛刺、强化特征)、定量参数(DWI-ADC值及IVIM-DWI(D值、D^(*)值及f值))之间的差异。结果其中HER-2阳性者18例(34.6%),HER-2阴性者34例(65.4%),HER-2阳性与HER-2阴性患者肿块MRI图像特征、D值及f值差异均无统计学意义(P>0.05);HER-2阳性患者ADC值(1.11±0.193)mm^(2)/s明显高于HER-2阴性患者ADC值(0.95±0.192)mm^(2)/s,差异有统计学意义(P<0.05);HER-2阳性患者D^(*)值(4.94±1.21)mm^(2)/s明显高于HER-2阴性患者D^(*)值(3.85±1.42)mm^(2)/s,差异有统计学意义(P<0.05)。结论MRI影像定量参数ADC值及D^(*)值与HER-2阳性表达有关。

Objective To investigate the characteristics of Multi-parameter in MRI images of breast cancer patients with positive HER-2.Methods MRI imaging data of 52 patients with invasive breast cancer confirmed by pathology in our hospital from January 2019 to November 2020 were retrospectively analyzed,And the differences between MRI image signs(lobulation,necrosis,burr and enhancement features)and quantitative parameters(DWI-ADC value and IVIM-DWI(D value,D^(*)value and F value)of 52 patients were analyzed.Results Among them,18 patients(34.6%)were HER-2 positive,and 34 patients(65.4%)were HER-2 negative.There was no significant difference in MRI image signs、D value and f value between HER-2 positive and HER-2 negative patients(P>0.05).ADC value of HER-2 positive patients(1.11±0.193)mm^(2)/s was significantly higher than that of HER-2 negative patients(0.95±0.192)mm^(2)/s,the difference was statistically significant(P<0.05).The D^(*)value of HER-2 positive patients(4.94±1.21)mm^(2)/s was significantly higher than that of HER-2 negative patients(3.85±1.42)mm^(2)/s,the difference was statistically significant(P<0.05).Conclusion MRI imaging quantitative parameters ADC value and D^(*)value are related to the positive expression of HER-2.