化学交换饱和转移技术在中枢神经系统疾病的研究进展

Advances in Chemical Exchange Saturation Transfer Techniques in Central Nervous System Diseases

化学交换饱和转移(chemical exchange saturation transfer,CEST)成像是MRI分子成像领域的一种创新工具,利用分子的特定MR频率(化学位移),在分子间化学交换基础上,通过检测水信号间接反映代谢物浓度的信息。目前CEST的成像方法已经在中枢神经系统疾病的早期诊断及疗效评估方面得到探索。

Chemical exchange saturation transfer(CEST)imaging is an innovative tool in the field of MRI molecular imaging,which uses the specific MR frequency of molecules(chemical shift)to indirectly reflect metabolite concentration information by detecting water signals on the basis of intermolecular chemical exchange.The CEST technique has been explored for early diagnosis and efficacy assessment of central nervous system diseases.