化疗相关认知障碍磁共振成像研究进展

Advances in multimodal MRI research on chemotherapy-related cognitive impairment

化疗相关认知障碍(chemotherapy-related cognitive impairment, CRCI)是指非中枢神经系统肿瘤化疗后引起的脑认知功能损害,其严重影响患者生活质量。随着MRI技术蓬勃兴起,结构和功能MRI已成为探究CRCI神经机制有效方法并不断取得进展。影像组学和人工智能在CRCI脑影像数据分析研究中亦得到逐渐发展和完善,并取得可观成果。本文就上述多模态MRI领域的CRCI研究进展予以综述,并探讨其临床价值,旨在为今后解读CRCI详细神经病理机制提供MRI新视野和新策略。

Chemotherapy-related cognitive impairment(CRCI)refers to the brain cognitive dysfunction caused by non-central nervous system tumor chemotherapy,which seriously affects the quality of life of patients.With the booming development of MRI technology,structural and functional MRI has become an effective method to explore the neural mechanisms of CRCI and has made continuous progress.Radiomics and artificial intelligence(AI)have also gradually developed and improved in the analysis of CRCI brain imaging data,yielding significant achievements.This paper reviews the research progress in the multimodal MRI field of CRCI and explores its clinical value.The aim is to provide a new perspective and new strategies for interpreting the detailed neuropathological mechanisms of CRCI using MRI.