酰胺质子转移磁共振成像在帕金森病中的研究进展

Research progress of amide proton transfer magnetic resonance imaging in Parkinson's disease

酰胺质子转移(amide proton transfer, APT)成像技术是近几年在化学交换饱和转移(chemical exchange saturation transfer, CEST)成像的基础上发展起来的一种新型MRI技术,它是在细胞和分子水平上对蛋白质浓度和pH进行无创检测和评价,可以间接反映细胞内代谢变化及病理生理信息。帕金森病(Parkinson's disease, PD)是第二常见的神经退行性疾病,目前尚无法根治,患者靠服药来控制病情、维持日常生活。早发现、早诊断PD是治疗的关键,可使患者受益巨大。通过APT成像技术可以评估PD患者各脑区蛋白质代谢状态,有助于实现PD的早期诊断。现就APT技术的基本原理、在PD中的研究进展及技术应用面临的挑战进行综述,旨在更好地了解APT成像技术,并为今后的研究提供参考和借鉴。

Amide proton transfer(APT)imaging technology is a new and original MRI technology developed in recent years on the basis of chemical exchange saturation transfer(CEST)imaging,which is based on the non-invasive detection and evaluation of protein concentration and pH at the cellular and molecular level,indirectly reflects the metabolic changes and physiological and pathological information in living cells.Parkinson's disease(PD)is the second most common neurodegenerative disease,which has not been eradicated yet,patients take drugs to control symptoms and maintain daily life.Early detection and diagnosis of PD is the key to treatment,and patients benefit greatly.APT imaging technology can evaluate the protein metabolism status of various brain regions in patients with PD and help to realize the early diagnosis of PD.This article reviews the basic principles of APT MRI technology,research progress in PD,and challenges faced in its application,aiming to better understand the APT imaging technology and provide reference for future research.