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甲状腺激素和抗缪勒管激素及FSH/LH比值与女性不孕不育的相关性 被引量:4

Clinical correlation of thyroid hormone,anti-Mullerian hormone and FSH/LH ratio with female infertility
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摘要 目的 分析甲状腺激素、抗缪勒管激素(AMH)、促卵泡生成素(FSH)/促黄体生成素(LH)比值与女性不孕不育的相关性。方法 选择2021年3月—2022年2月台山市妇幼保健院收治的60例不孕不育女性患者作为不孕不育组,另外选择同期在该院进行健康体检的60名已生育健康女性作为健康对照组。使用电化学发光免疫分析仪对两组甲状腺激素[包括游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)]、AMH、FSH/LH比值进行检测。汇总检测结果,将两组存在差异的资料带入Logistic回归方程计算,分析甲状腺激素、AMH、FSH/LH对女性不孕不育的影响。结果 不孕不育组与健康对照组的FT_(3)、FT_(4)水平及阳性率比较差异均无统计学意义。不孕不育组的TSH、FSH/LH水平及阳性率均明显高于健康对照组,AMH水平及阳性率均明显低于健康对照组[TSH(mU/L):2.56±0.35比1.64±0.25,FSH/LH:2.45±0.30比1.46±0.26,TSH阳性率:88.33%比1.67%,FSH/LH阳性率:75.00%比3.33%,AMH(μg/L):1.58±0.56比5.40±1.20,AMH阳性率:3.33%比80.00%,均P<0.05]。将发生不孕不育作为因变量Y,TSH、AMH以及FSH/LH分别作为自变量X_(1)、X_(2)、X_(3),将差异有统计学意义的项目带入Logistic回归方程计算,结果显示TSH>2.5 mU/L、AMH<1.5μg/L、FSH/LH>2均为女性不孕不育的危险因素,优势比(OR)分别为1.674、1.552、1.606,95%可信区间(95%CI)分别为-1.103~1.725、-1.143~1.888、-1.149~2.016)。结论 甲状腺激素、AMH、FSH/LH水平异常是导致女性不孕不育的主要因素,其中TSH、AMH以及FSH/LH是较敏感的关键指标,能为临床诊治女性不孕不育提供重要参考依据。 Objective To analyze the clinical correlation of thyroid hormones,anti-Mullerian hormone(AMH)and follicle stimulating hormone/luteinizing hormone(FSH/LH)ratio with female infertility.Methods The infertile female patients admitted to Taishan Maternal and Child Health Hospital from March 2021 to February 2022 were selected as infertility group,and 60 healthy women during the same period who had given birth and underwent health examinations in the hospital were selected as healthy control group.The levels of thyroid hormones[including free triiodothyronine(FT_(3)),free thyroxine(FT_(4))and thyroid hormone(TSH)],AMH and FSH/LH in two groups were detected using electrochemiluminescence immunoanalyzer.The test results were summarized,the data with differences between the two groups were brought into the Logistic regression equation and calculated,and the impact of thyroid hormones,AMH and FSH/LH on female infertility were analyzed.Results There were no significant differences in the levels and positive rates of FT_(3) and FT_(4) between infertility group and healthy control group.In infertility group,the levels and positive rates of TSH and FSH/LH were significantly higher than those in healthy control group,and the level and positive rate of AMH were significantly lower than those in healthy control group[TSH(mU/L):2.56±0.35 vs.1.64±0.25,FSH/LH:2.45±0.30 vs.1.46±0.26,positive rate of TSH:88.33%vs.1.67%,positive rate of FSH/LH:75.00%vs.3.33%,AMH(μg/L):1.58±0.56 vs.5.40±1.20,positive rate of AMH:3.33%vs.80.00%,all P<0.05].The occurrence of female infertility was seen as dependent variable Y,and TSH,AMH and FSH/LH were seen as independent variables X_(1),X_(2) and X_(3).Logistic regression equation indicated that the risk factors of female infertility were TSH>2.5 mU/L,AMH<1.5 ng/L and FSH/LH>2,the odds ratio(OR)was 1.674,1.552 and 1.606,and the 95%confidence interval(95%CI)was-1.103 to 1.725,-1.143 to 1.888 and-1.149 to 2.016.Conclusion The major influence factors of female infertility are thyroid hormones,AMH and FSH/LH abnormalities,among which TSH,AMH and FSH/LH could be the key indicators of predicting the female infertility,and provide reference on the clinical diagnosis and treatment of female infertility.
作者 周杰敏 何安平 周国亮 Zhou Jiemin;He Anping;Zhou Guoliang(Department of Clinical Laboratory,Taishan Maternal and Child Health Hospital,Taishan 529200,Guangdong,China)
出处 《实用检验医师杂志》 2023年第1期1-4,共4页 Chinese Journal of Clinical Pathologist
关键词 甲状腺激素 抗缪勒管激素 促卵泡生成素 促黄体生成素 不孕不育 相关性 Thyroid hormone Anti-Mullerian hormone Follicle stimulating hormone Luteinizing hormone Infertility Correlation
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