血糖和糖化血红蛋白检测在健康体检中的应用

Application of blood glucose and glycated hemoglobin detection in health examination

目的 探讨血糖和糖化血红蛋白(HbA1c)检测在健康体检中的应用。方法 选择2022年10—12月在平湖市当湖街道社区卫生服务中心体检中心进行健康体检的117名体检者作为研究对象,其中男性37例,女性80例;根据年龄分为30~40岁组(24例),41~50岁组(57例),51~60岁组(31例),61~70岁组(5例)。使用全自动生化分析仪,采用葡萄糖氧化酶法检测所有受检者空腹血糖(FBG);使用全自动糖化血红蛋白分析仪,采用高效液相色谱法检测HbAlc。分析并比较不同HbA1c水平体检者的FBG以及不同年龄段和不同性别受检者FBG与HbA1c的异常检出率。结果 HbAlc<0.050的受检者FBG水平明显低于HbAlc为0.050~0.060的受检者,且HbAlc>0.060受检者的FBG水平明显高于HbAlc<0.050和HbAlc为0.050~0.060的受检者(mmol/L:9.53±2.42比5.10±0.46、5.34±0.51,均P<0.05);随着受检者HbAlc水平的升高,FBG水平也逐渐升高。随年龄增长,受检者FBG和HbAlc的异常检出率也逐渐升高,30~40岁组为4.2%、4.2%,41~50岁组为8.77%、8.77%,51~60岁组为22.58%、32.26%,61~70岁组为40.00%、60.00%。117名受检者FBG异常检出率为12.82%,HbAlc异常检出率为16.24%。男性受检者的FBG及HbAlc异常检出率均明显高于女性(FBG:24.32%比7.50%,HbA1c:32.43%比8.75%,均P<0.05)。结论 血糖和HbAlc联合检测能够提高糖尿病的早期诊断率,可作为糖尿病的早期诊断指标,应用于健康体检中具有非常重要的意义。

Objective To explore the application of blood glucose and glycosylated hemoglobin A1c(HbA1c)in health examination.Methods A total of 117 physical examinees from the physical examination center of Danghu Street Community Health Service Center of Pinghu City from October to December,2022 were selected as research objects,including 37 males and 80 females.According to age,there were 24 cases in 30-40 years old group,57 cases in 41-50 years old group,31 cases in 51-60 years old group,and 5 cases in 61-70 years old group.Using automatic biochemical analyzer,the level of fasting blood glucose(FBG)of all subjects was detected by glucose oxidase method,and the level of HbAlc was detected by high performance liquid chromatography with automatic glycosylated hemoglobin analyzer.The abnormal detectable rates of FBG and HbA1c in physical examinees with different HbA1c levels and subjects of different ages and genders were analyzed and compared.Results The FBG level of subjects with HbAlc<0.050 was significantly lower than that of subjects with HbAlc of 0.050-0.060,and the FBG level of subjects with HbAlc>0.060 was significantly higher than those of subjects with HbAlc<0.050 and HbAlc of 0.050-0.060(mmol/L:9.53±2.42 vs.5.10±0.46,5.34±0.51,both P<0.05).With the increase of age,the abnormal detectable rates of FBG and HbAlc increased gradually,with 4.2%and 4.2%in 30-40 years old group,8.77%and 8.77%in 41-50 years old group,22.58%and 32.26%in 51-60 years old group,and 40.00%and 60.00%in 61-70 years old group.The detectable rate of FBG abnormality was 12.82%,and the detectable rate of HbAlc abnormality was 16.24%.The abnormal detectable rates of FBG and HbAlc in males were significantly higher than those in females(FBG:24.32%vs.7.50%,HbAlc:32.43%vs.8.75%,both P<0.05).Conclusion The combined detection of blood glucose and HbAlc could improve the early diagnostic rate of diabetes mellitus,and could be used as early detection and diagnosis indexes of diabetes mellitus,which is of great significance in health examination.