血清免疫固定电泳联合尿免疫固定电泳及骨髓细胞形态学观察对多发性骨髓瘤的诊断效果

Effect of serum immunofixation electrophoresis combined with urine immunofixation electrophoresis and bone marrow cell morphological observation on diagnosis of multiple myeloma

目的 分析血清免疫固定电泳联合尿免疫固定电泳以及骨髓细胞形态学观察对多发性骨髓瘤的诊断价值。方法 选择2021年1月—2022年4月平邑县人民医院收治的80例多发性骨髓瘤患者作为研究对象。采用血清免疫固定电泳、尿免疫固定电泳以及骨髓细胞形态学观察进行诊断,分别观察上述诊断方法单独及联合应用对多发性骨髓瘤的检出率。结果 80例患者中血清免疫固定电泳共检出多发性骨髓瘤73例,检出率为91.25%;尿免疫固定电泳共检出74例,检出率为92.50%;骨髓细胞形态学观察共检出70例,检出率为87.50%;三种方法联合应用共检出79例,总检出率为98.75%,明显高于各方法单独应用(均P<0.05)。结论 临床在诊断多发性骨髓瘤患者时,可将多种检测方法联合应用,如血清免疫固定电泳、尿免疫固定电泳以及骨髓细胞形态学观察,联合应用有助于提高疾病的检出率,便于临床医师制定相应的治疗方案,做到针对性治疗,从而改善患者预后。

Objective To analyze the diagnostic value of serum immunofixation electrophoresis combined with urine immunofixation electrophoresis and bone marrow cell morphological observation in multiple myeloma.Methods A total of 80 patients with multiple myeloma admitted to Pingyi County People's Hospital from January 2021 to April 2022 were selected as study objects.Serum immunofixation electrophoresis,urine immunofixation electrophoresis and bone marrow cell morphological observation were used for diagnosis,and the detectable rate of multiple myeloma was observed separately and in combination with the above diagnostic methods.Results A total of 73 cases of multiple myeloma were detected by serum immunofixation electrophoresis among 80 patients,with a detectable rate of 91.25%.A total of 74 cases were detected by urine immunofixation electrophoresis,with a detectable rate of 92.50%.A total of 70 cases were detected by bone marrow cytology,with a detectable rate of 87.50%.A total of 79 cases were detected in the combined application of three methods,and the total detectable rate was 98.75%,which was significantly higher than that of each method alone(all P<0.05).Conclusion In the clinical diagnosis of patients with multiple myeloma,a variety of diagnostic methods,such as serum immunofixation electrophoresis,urine immunofixation electrophoresis and bone marrow cell morphological observation,could be combined to improve the detectable rate of the disease,help facilitate doctors to carry out corresponding treatment plans,achieve targeted treatment,and help improve the prognosis of the disease.