CTA在评估大动脉炎病情活动性中的临床应用价值

Value of CT Angiography in Assessing the Activity of Takayasu Arteritis

目的探讨CT血管成像(CT angiography,CTA)在评估大动脉炎活动性中的价值。方法本研究为回顾性病例对照研究。连续纳入2017年1月~2021年12月在笔者医院住院并诊断为大动脉炎患者29例,收集CT血管成像、血清学炎性指标及其他临床资料,使用酶联免疫吸附试验法(enzyme-linked immunosorbent assay,ELISA)测定正五聚蛋白-3(pentraxins-3,PTX-3)水平。应用美国国立卫生研究院提出的Kerr评分评估活动性,并将病例分为活动组与非活动组。结果活动组管壁相对强化比率要明显高于非活动组(P=0.02),而最大壁厚比较,差异无统计学意义(P=0.34)。相对强化比率与PTX-3、白细胞计数、血小板计数有关。结论血管壁相对强化比率在大动脉炎活动性评估中有一定的价值,有助于临床医生早期识别活动期大动脉炎患者,为及时治疗提供可能性。

Objective To evaluate the value of CT angiography in assessing the activity of takayasu arteritis(TA).Methods We continuously enrolled 29 patients diagnosed with TA who were hospitalized in our hospital from January 2017 to December 2021.CT angiography,Serological inflammatory markers and other clinical data were collected.Serum pentraxins-3(PTX-3)levels were detected by enzyme-linked immunosorbent assay(ELISA).The Kerr score proposed by the National Institutes of Health was used to assess aortitis activity,and subjects were divided into active and inactive groups.Results The relative post-contrast enhancement ratio of the thickened wall was higher in active TA than in inactive TA(P=0.02),but there was no statistically significant difference in the maximum wall thickness(P=0.34).The relative enhancement rate was moderately correlated with PTX-3,white blood cell count and platelet count.Conclusion The relative enhancement ratio of vascular wall has a certain value in the evaluation of aorta activity,which can help clinicians to identify patients with active aorta early and provide timely treatment.